TP53BP1 抗体 (AA 1-50)
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北京 101111
Quick Overview for TP53BP1 抗体 (AA 1-50) (ABIN1532493)
抗原
See all TP53BP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-50
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原理
- 53BP1 Antibody
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特异性
- 53BP1 Polyclonal Antibody detects endogenous levels of 53BP1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human 53BP1. AA range:1-50
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亚型
- IgG
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anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 574-773) antibody
TP53BP1 适用: 人 IHC, WB, ELISA, FACS 宿主: 小鼠 Monoclonal 6B3E10 unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibodyKD Validated TP53BP1 适用: 人 WB, FACS, IF (p) 宿主: 小鼠 Monoclonal 24GB13320 unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 350-400) antibodyTP53BP1 适用: 人, 小鼠 IHC, WB, FACS, IP 宿主: 兔 Monoclonal BL-250-1H11 unconjugated Recombinant Antibody
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibodyTP53BP1 适用: 人 IHC, WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 350-400) antibodyTP53BP1 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyKO Validated TP53BP1 适用: 人 WB, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 1239-1972) antibodyTP53BP1 适用: 人 IHC, WB, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (pSer25), (pSer29) antibodyTP53BP1 适用: 人 IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (C-Term) antibodyTP53BP1 适用: 人 IHC 宿主: 兔 Monoclonal HMV324 unconjugated Recombinant Antibody
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (C-Term) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 IHC, WB, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))
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别名
- 53BP1
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背景
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Synonyms: TP53BP1, Tumor suppressor p53-binding protein 1, 53BP1, p53-binding protein 1, p53BP1
Background: function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at 'Lys-20'. Has low affinity for histone H4 containing monomethylated 'Lys-20'. Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20'. Has low affinity for histone H3 that has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro). Does not bind unmethylated histone H3.,
Gene Name: TP53BP1
Protein Name: Tumor suppressor p53-binding protein 1
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分子量
- 213 kDa
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基因ID
- 7158
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OMIM
- 605230
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UniProt
- Q12888
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途径
- DNA Damage Repair
抗原
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