TP53BP1 抗体 (C-Term)
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北京 101111
Quick Overview for TP53BP1 抗体 (C-Term) (ABIN3044038)
抗原
See all TP53BP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Anti-53BP1/TP53BP1 Antibody
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序列
- ERIGFKQHPK YKHDYVSH
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins
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预测反应
- identical to the related mouse sequence.
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产品特性
- Anti-53BP1/TP53BP1 Antibody. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human 53BP1, identical to the related mouse sequence.
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亚型
- IgG
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anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 574-773) antibody
TP53BP1 适用: 人 IHC, WB, ELISA, FACS 宿主: 小鼠 Monoclonal 6B3E10 unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibodyKD Validated TP53BP1 适用: 人 WB, FACS, IF (p) 宿主: 小鼠 Monoclonal 24GB13320 unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 350-400) antibodyTP53BP1 适用: 人, 小鼠 IHC, WB, FACS, IP 宿主: 兔 Monoclonal BL-250-1H11 unconjugated Recombinant Antibody
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 1239-1972) antibodyTP53BP1 适用: 人 IHC, WB, ELISA, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibodyTP53BP1 适用: 人 IHC, WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (AA 350-400) antibodyTP53BP1 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyKO Validated TP53BP1 适用: 人 WB, IF, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (pSer25), (pSer29) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 ELISA, ICC, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (N-Term) antibodyTP53BP1 适用: 人, 小鼠, 大鼠 IHC, WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) (C-Term) antibodyTP53BP1 适用: 人 IHC 宿主: 兔 Monoclonal HMV324 unconjugated Recombinant Antibody
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应用备注
- Western blot, 0.1-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat Immunocytochemistry , 0.5-1 μg/mL, Human
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))
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别名
- TP53BP1
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背景
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Background: TP53BP1 (Tumor Protein p53-Binding Protein 1), also called 53BP1, is a protein that in humans is encoded by the TP53BP1 gene. Iwabuchi et al. (1998) mapped the TP53BP1 gene to 15q15-q21 by FISH. Iwabuchi et al. (1994) showed that TP53BP1 binds to the conformationally sensitive central domain of wildtype p53 but not to mutant p53 in vitro. Immunoblot analysis by Iwabuchi et al. (1998) showed that expression of TP53BP1 or TP53BP2 enhances the transactivation function of p53 and induces the expression of p21 (CDKN1A). Wang et al. (2002) used small interfering RNA ed against TP53BP1 in mammalian cells to demonstrate that TP53BP1 is a key transducer of the DNA damage checkpoint signal. TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.
Gene Full Name: tumor protein p53 binding protein 1
Sequence Similarities: Contains 2 BRCT domains.
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分子量
- 450 kDa
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基因ID
- 7158
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UniProt
- Q12888
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途径
- DNA Damage Repair
抗原
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