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TACI 抗体 (PE)

TNFRSF13B 适用: 人 FACS 宿主: 小鼠 Monoclonal 11H3 PE
产品编号 ABIN1504150
发货至: 中国
  • 抗原 See all TACI (TNFRSF13B) 抗体
    TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))
    适用
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    宿主
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    小鼠
    克隆类型
    • 35
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    单克隆
    标记
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    This TACI antibody is conjugated to PE
    应用范围
    • 41
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    Flow Cytometry (FACS)
    特异性
    This antibody reacts with CD267 antigen. Clone 11H3 has an agonistic activity and it doesn't block binding of BAFF to TACI.
    交叉反应 (详细)
    Species reactivity (tested):Human
    纯化方法
    Protein A agarose
    克隆位点
    11H3
    亚型
    IgG2a
    Top Product
    Discover our top product TNFRSF13B Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    50 tests in 1 mLvolume of PBS containing 1 % BSA and 0.09 % NaN3
  • 抗原
    TACI (TNFRSF13B) (Tumor Necrosis Factor Receptor Superfamily, Member 13B (TNFRSF13B))
    别名
    CD267 / TACI (TNFRSF13B 产品)
    别名
    CD267 antibody, CVID antibody, CVID2 antibody, RYZN antibody, TACI antibody, TNFRSF14B antibody, TNFRSF13B antibody, 1200009E08Rik antibody, Taci antibody, TNF receptor superfamily member 13B antibody, tumor necrosis factor receptor superfamily, member 13b antibody, TNFRSF13B antibody, Tnfrsf13b antibody
    背景
    CD267, also known as TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) or TNFRSF13B, is a member of the tumor necrosis factor (TNF) receptor family that serves as a receptor for B-cell activating factor of the TNF family (BAFF/CD257) and as a proliferation-inducing ligand (APRIL/CD256). BAFF and APRIL bind both TACI and BCMA (B cell maturation Ag/CD269), with BAFF additionally and exclusivel y binding the BAFF receptor (BAFF-R/CD268) while APRIL can also bind to heparin sulfate proteoglycan s (HSPG). TACI is expressed on B cells and activated T cells. BC MA is exclusively expressed on B cells, whereas BAFF-R is expressed mainly on B cells but also on T cells. It is reported that mutations of CD267/TACI are showed in patients with IgA deficiency and common variable immunodeficiency (CVID). Sakurai et al ., reported that TACI positively regulated APRIL-induced IgA production in collaboration with HSPG and TACI negatively regulated BAFF-induced B-cell proliferation and production of IgA and IgG.Synonyms: TNFRSF13B, Transmembrane activator and CAML interactor, Tumor necrosis factor receptor superfamily member 13B
    基因ID
    23495
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