ALKBH1
适用: 小鼠, 大鼠
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
宿主: 兔
Polyclonal
unconjugated
应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
溶解方式
Add 50 μL of distilled water to a final concentration of 1 mg/mL.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store lyophilized at 2-8 °C for one month or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.
ALKBH1 is a dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. This requires molecular oxygen, alpha-ketoglutarate and iron. ALKBH1 may have a role in placental trophoblast lineage differentiation, has DNA lyase activity and introduces double-stranded breaks at abasic sites. It cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.Synonyms: ABH, ALKBH, Alkylated DNA repair protein alkB homolog 1