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Retinoblastoma 1 抗体 (pSer795)

This anti-Retinoblastoma 1 antibody is a 小鼠 单克隆 antibody detecting Retinoblastoma 1 in WB. Suitable for 人.
产品编号 ABIN1449257
发货至: 中国

Quick Overview for Retinoblastoma 1 抗体 (pSer795) (ABIN1449257)

抗原

See all Retinoblastoma 1 (RB1) 抗体
Retinoblastoma 1 (RB1)

适用

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宿主

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  • 30
小鼠

克隆类型

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单克隆

标记

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This Retinoblastoma 1 antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

28B5
  • 抗原表位

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    pSer795

    特异性

    This antibody specifically recognizes human Rb withphosphorylated at Ser795.

    亚型

    IgG2b
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

    储存液

    Without preservative

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Upon receipt, store (in aliqouts) at -20 °C.
  • 抗原

    Retinoblastoma 1 (RB1)

    别名

    Retinoblastoma-Associated Protein / RB1

    背景

    Retinoblastoma protein (Rb), the tumor suppressor product of the retinoblastoma susceptibility gene, is a 110 kDa protein that functions as a negative regulator of the cell cycle by arresting cells in the G 1 phase and halting inappropriate cell proliferation (Ref1 . At the transcriptional level, Rb protein exerts its growth suppressive function by binding to transcription factors including E2F1, PU.1, ATF2, UBF, Elf-1 and c-Abl (Ref 2-4 . Loss of Rb function leads to uncontrolled cell growth and tumor development and is found in all retinoblastomas and in a variety of other human malignancies. The ability of Rb protein to inhibit the transcription and the cell cycle progression is inactivated by phosphorylation, which is catalyzed by the cyclin-d ependent protein kinases.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110

    基因ID

    5925

    NCBI登录号

    NP_000312

    UniProt

    P06400

    途径

    Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy
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