ZC3HC1 抗体 (pSer354) (Alexa Fluor 350)
-
- 抗原 See all ZC3HC1 抗体
- ZC3HC1 (Zinc Finger, C3HC-Type Containing 1 (ZC3HC1))
-
抗原表位
- pSer354
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This ZC3HC1 antibody is conjugated to Alexa Fluor 350
-
应用范围
- Western Blotting (WB)
- 交叉反应
- 人
- 预测反应
- Mouse,Rat,Dog,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human NIPA around the phosphorylation site of Ser354
- 亚型
- IgG
- Top Product
- Discover our top product ZC3HC1 Primary Antibody
-
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (AA 1-260) antibody
ZC3HC1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (C-Term) antibodyZC3HC1 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) antibodyZC3HC1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (AA 1-260) antibodyZC3HC1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (Tyr713) antibodyZC3HC1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (AA 320-369) antibodyZC3HC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (AA 320-369) antibodyZC3HC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- IF(IHC-P) 1:50-200
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
-
- 抗原
- ZC3HC1 (Zinc Finger, C3HC-Type Containing 1 (ZC3HC1))
- 别名
- NIPA (ZC3HC1 产品)
- 别名
- 1110054L24Rik antibody, AU018540 antibody, AU019789 antibody, HSPC216 antibody, Nipa antibody, NIPA antibody, RGD1561099 antibody, zinc finger, C3HC type 1 antibody, zinc finger C3HC-type containing 1 antibody, zinc finger, C3HC-type containing 1 antibody, Zc3hc1 antibody, ZC3HC1 antibody
- 背景
-
Synonyms: NIPA phospho S354, NIPA phospho Ser354, p-NIPA S354, p-NIPA Ser354, hNIPA, Nuclear interacting partner of ALK, Nuclear interacting partner of anaplastic lymphoma kinase, ZC3HC1, Zinc finger C3HC type containing 1, NIPA_HUMAN.
Background: The regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. NIPA (nuclear interaction partner of ALK) is a human F-box-containing protein that defines an SCF-type E3 ligase (SCFNIPA) controlling mitotic entry. Assembly of this SCF complex is regulated by cell-cycle-dependent phosphorylation of NIPA, which restricts substrate ubiquitination activity to interphase. Nuclear cyclin B1 is a substrate of SCFNIPA. Inactivation of NIPA by RNAi results in nuclear accumulation of cyclin B1 in interphase, activation of cyclin B1-Cdk1 kinase activity, and premature mitotic entry. Thus, SCFNIPA-based ubiquitination may regulate S-phase completion and mitotic entry in the mammalian cell cycle.
- 基因ID
- 51530
-
