UNC5B 抗体 (AA 188-260) (Alexa Fluor 350)
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- 抗原 See all UNC5B 抗体
- UNC5B (Netrin receptor UNC5B (UNC5B))
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抗原表位
- AA 188-260
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This UNC5B antibody is conjugated to Alexa Fluor 350
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人, 小鼠, 大鼠
- 预测反应
- Dog,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human UNC5B
- 亚型
- IgG
- Top Product
- Discover our top product UNC5B Primary Antibody
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anti-Netrin receptor UNC5B (UNC5B) (AA 404-517) antibody
UNC5B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 188-260) antibodyUNC5B 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 27-126) antibodyUNC5B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A9 unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 507-541) antibodyUNC5B 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB52980 unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 27-126) antibodyUNC5B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 629-643) antibodyVerified UNC5B 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Netrin receptor UNC5B (UNC5B) (AA 290-377) antibodyUNC5B 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- UNC5B (Netrin receptor UNC5B (UNC5B))
- 别名
- UNC5B/UNC5H2 (UNC5B 产品)
- 别名
- unc5h2 antibody, 6330415E02Rik antibody, A630020F16 antibody, D10Bwg0792e antibody, Unc5h2 antibody, UNC5H2 antibody, p53RDL1 antibody, UNC5C antibody, UNC5B antibody, p53rdl1 antibody, unc-5 netrin receptor B antibody, unc-5 netrin receptor B L homeolog antibody, unc5b antibody, Unc5b antibody, UNC5B antibody, unc5b.L antibody
- 背景
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Synonyms: Netrin receptor UNC5B, Netrin receptor UNC5B Precursor, p53 regulated receptor for death and le, p53 regulated receptor for death and le protein 1, p53-regulated receptor for death and le protein 1, p53RDL1, Protein unc-5 homolog 2, Protein unc-5 homolog B, Protein XUNC 5, Transmembrane receptor Unc5H2, Unc 5 homolog 2, Unc 5 homolog B, UNC 5B, Unc5 C.elegans homolog b, Unc5b, UNC5B_HUMAN, UNC5H2.
Background: The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. In fact, UNC5H receptors express widely in cells that migrate, where they bind the G protein G Alpha 1-2 to inhibit G protein signaling. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain, but this activity is blocked by the binding of netrin-1. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. Hence, in the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, cartilage, kidney and hematopoietic and immune tissues.
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