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SLC12A6 抗体 (AA 401-500)

SLC12A6 适用: 人 ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN1386627
发货至: 中国
  • 抗原 See all SLC12A6 抗体
    SLC12A6 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6))
    抗原表位
    • 14
    • 8
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    适用
    • 46
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 42
    • 2
    • 2
    克隆类型
    • 45
    • 1
    多克隆
    标记
    • 21
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SLC12A6 antibody is un-conjugated
    应用范围
    • 27
    • 23
    • 20
    • 12
    • 12
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    预测反应
    Human,Mouse,Rat,Cow,Sheep,Pig,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human SLC12A6/KCC3
    亚型
    IgG
    Top Product
    Discover our top product SLC12A6 Primary Antibody
  • 应用备注
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    SLC12A6 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6))
    别名
    SLC12A6/KCC3 (SLC12A6 产品)
    别名
    Kcc3 antibody, ACCPN antibody, KCC3 antibody, KCC3A antibody, KCC3B antibody, 9530023I19Rik antibody, gaxp antibody, solute carrier family 12, member 6 antibody, solute carrier family 12 member 6 antibody, Slc12a6 antibody, SLC12A6 antibody
    背景

    Synonyms: ACCPN, Furosemide sensitive KCl cotransporter 3, Gaxp, KCC 3, KCC 3A, KCC 3B, KCC3 A, KCC3, KCC3 B, KCC3A, KCC3B, Potassium chloride cotransporter 3, Potassium chloride cotransporter KCC3a S3, SLC12 A6, SLC12A 6, Solute carrier family 12 potassium/chloride transporters, member 6, Solute carrier family 12, member 6, S12A6_HUMAN.

    Background: The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.

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