SPRY1 抗体 (AA 221-319)
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- 抗原 See all SPRY1 抗体
- SPRY1 (Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1))
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抗原表位
- AA 221-319
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SPRY1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人
- 预测反应
- Mouse,Rat,Dog,Cow,Pig,Horse,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Sprouty1
- 亚型
- IgG
- Top Product
- Discover our top product SPRY1 Primary Antibody
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anti-Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1) (AA 1-110) antibody
SPRY1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3H4 unconjugated
anti-Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1) (AA 112-303) antibodySPRY1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1) (C-Term) antibodyVerified SPRY1 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1) (AA 1-178) antibodySPRY1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1) antibodySPRY1 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 3H4 unconjugated
anti-Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1) (AA 1-110) antibodySPRY1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1) (AA 1-319) antibodySPRY1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1) (AA 1-111) antibodySPRY1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3H4 unconjugated
anti-Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1) (AA 118-309) antibodySPRY1 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1) (AA 1-319) antibodySPRY1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- SPRY1 (Sprouty Homolog 1, Antagonist of FGF Signaling (SPRY1))
- 别名
- Sprouty1 (SPRY1 产品)
- 别名
- hSPRY1 antibody, SPRY1 antibody, LOC100223875 antibody, hspry1 antibody, xspry1 antibody, sprouty antibody, sprouty1 antibody, sprouty-1 antibody, Xtsprouty1 antibody, spry1a antibody, spry1b antibody, sprouty RTK signaling antagonist 1 antibody, sprouty RTK signaling antagonist 1 L homeolog antibody, sprouty RTK signaling antagonist 1 S homeolog antibody, sprouty homolog 1 (Drosophila) antibody, SPRY1 antibody, Spry1 antibody, spry1 antibody, spry1.L antibody, spry1.S antibody
- 背景
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Synonyms: Sprouty 1, Sprouty-1, hSPRY1, Protein sprouty homolog 1, Sprouty homolog 1 antagonist of FGF signaling, Sprouty homolog 1, Spry-1, Spry1, SPY1_HUMAN.
Background: Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well-conserved cysteine-rich C-terminal domain with their Drosophila counterparts. Both Sprouty 1 and 2 are anchored to membranes by palmitoylation, associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on Serine residues. Upon stimulation, a subset is recruited to the leading edge of the plasma membrane. Sprouty 2 can associate with c-Cbl, a down regulator of RTK signaling, and inhibits the activities of several growth factors. Sprouty 2 also functions as a negative regulator of embryonic lung morphogenesis and growth. The well-conserved C-terminus of Sprouty contains two domains which are necessary for Sprouty 2 co-localization with microtubules and translocation to membrane ruffles. In addition, the C-terminus is required for the inhibition of cell migration and proliferation. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes.
- 途径
- EGFR Signaling Pathway, EGFR Downregulation
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