Lamin A/C 抗体
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北京 101111
Quick Overview for Lamin A/C 抗体 (ABIN126715)
抗原
See all Lamin A/C (LMNA) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The monoclonal antibody cocktail decorates the karyoskeleton, i.e. the intermediate filament equivalent of the nucleus. Polypeptides reacting: Lamin isotypes of Mr 60 - 75 kDa.
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纯化方法
- Protein A affinity chromatography
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免疫原
- Nuclear pore complex-lamina fraction of Xenopus laevis (XLKE-A6 cells)
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亚型
- IgG1
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anti-Lamin A/C (LMNA) (AA 403-572) antibody
LMNA 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Lamin A/C (LMNA) antibodyKO Validated LMNA 适用: 人 WB, IF, IP, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lamin A/C (LMNA) (pSer392) antibodyLMNA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lamin A/C (LMNA) antibodyLMNA 适用: 人 IHC, ELISA, IF, IP, FACS 宿主: 兔 Monoclonal 4H7 unconjugated Recombinant Antibody
anti-Lamin A/C (LMNA) antibodyLMNA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 4E7 unconjugated
anti-Lamin A/C (LMNA) (AA 481-646) antibodyLMNA 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Lamin A/C (LMNA) (AA 455-469) antibodyLMNA 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lamin A/C (LMNA) (C-Term) antibodyLMNA 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 猴, 兔, 马, 小鸡, Hamster, 绵羊, 豚鼠, Avian, Cat, 驴, 山羊 WB 宿主: 山羊 Polyclonal unconjugated
anti-Lamin A/C (LMNA) antibodyLMNA 适用: 人, 小鼠, 大鼠, Cow, 犬 WB, IHC, ICC, FACS, IHC (fro) 宿主: 小鼠 Monoclonal 133A2 unconjugated
anti-Lamin A/C (LMNA) (AA 1-664) antibodyLMNA 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blotting. Immunofluorescence microscopy. Immunohistochemistry: dilute further 1: 10 (incubation time 1 h at room temperature).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore in 1.0 mL distilled water.
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缓冲液
- 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- Use of sodium azide as a preservative will substantially inhibit the enzyme activity of horseradish peroxidase.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Lamin A/C (LMNA)
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别名
- Lamin-A/C (LMNA)
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背景
- Nuclear Lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type Lamins and B-type Lamins. The A-type Lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. Lamin A, Lamin C and Lamin Adel 10, while the B-type Lamins include two proteins arising from two distinct genes, i.e. Lamin B1 and Lamin B2. Recent evidence has revealed that mutations in A-type Lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type Lamins coincides with cell differentiation and as A-type Lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type Lamins.Synonyms: 70 kDa Lamin, LMN1, LMNA, Lamin A, Lamin A + C, Lamin-A/C, NY-REN-32, NYREN32, Nuclear Envelope Marker, Renal carcinoma antigen NY-REN-32
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基因ID
- 4000
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NCBI登录号
- NP_005563
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UniProt
- P02545
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途径
- Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
抗原
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