CDC7 抗体 (Kinase Domain)
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Quick Overview for CDC7 抗体 (Kinase Domain) (ABIN122614)
抗原
See all CDC7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Kinase Domain
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特异性
- Reacts with CDC7-Related Protein Kinase (CDC7L1) (family: Protein Kinase, subfamily: CDC7)
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产品特性
- Synonyms: CDC7L1, CDC7-related kinase, HsCdc7, huCdc7, Cell division cycle 7-related protein kinase
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纯化方法
- Peptide immunogen affinity column
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免疫原
- Synthetic peptide - KLH conjugatedEpitope: Kinase domain of humanGenename: CDC7Remarks: The immunizing peptide shows 63 % identity (79 % similarity) with mouse.
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应用备注
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Immunohistochemistry on paraffin embedded sections: 5,2 μg/mLntigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove fromheat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween(TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.7, containing 0.01 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-80 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- CDC7 (Cell Division Cycle 7 (CDC7))
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别名
- CDC7
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背景
- CDC7L1, CDC7 type protein kinase, regulates firing of the origins of initiation in DNA replication. CDC7L1 forms a complex with a Dbf4-related regulatory subunit to generate an active kinase. Mini-chromosome maintenance protein (MCM) is the major physiological target of Cdc7L1. At least three mRNA variants have been reported. Overexpression of the CDC7L1 protein may be associated with neoplastic transformation for some tumors. CDC7L1 has been documented in a wide range of tissues. One variant is expressed ubiquitously in human tissues while at least one other has been shown to be testis-specific. ESTs have been isolated from several tissue libraries, including normal embryo, gallbladder, lymph node and thymus and cancerous duodenum and embryo.Synonyms: CDC7-related kinase, CDC7L1, Cell division cycle 7-related protein kinase, HsCdc7, huCdc7
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基因ID
- 8317
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UniProt
- O00311
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途径
- Mitotic G1-G1/S Phases, DNA Replication
抗原
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