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PAK1 抗体 (pThr423)

Name: PAK1 抗体 (pThr423)
SKU: ABIN117984
Availability: OutOfStock

The 兔多克隆 anti-PAK1 antibody (ABIN117984) specifically detects PAK1 in EIA. The antibody is reactive with 人 samples.

产品编号 ABIN117984

发货至: 中国

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Quick Overview for PAK1 抗体 (pThr423) (ABIN117984)

抗原

See all PAK1 抗体

PAK1 (P21-Activated Kinase 1 (PAK1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This PAK1 antibody is un-conjugated

应用范围

Enzyme Immunoassay (EIA)

Discover our top product PAK1 Primary Antibody

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pThr423

序列

P-E-Q-S-K-R-S-(pT)-M-V-G-T-P-Y (aa 413-433 of human PAK1, 408-428 of human PAK2 and 411-431 of human PAK3)

特异性

This affinity purified antibody is directed against human PAK (p21-GTPase Activated Protein Kinase). The product was affinity purified from monospecific antiserum by immunoaffinity purification. Antiserum was first purified against the phosphorylated form of the immunizing peptide. The resultant affinity purified antibody was then cross-adsorbed against the non-phosphorylated form of the immunizing peptide. This phospho specific polyclonal antibody is specific for phosphorylated pT423 of Human PAK 1/2/3. Reactivity with non-phosphorylated PAK 1/2/3 is less than 1 % by ELISA. Cross reactivity with PAK 1/2/3 from other species has not been determined.

纯化方法

Immunoaffinity chromatography.

免疫原

Human PAK 1/2/3 phospho peptide corresponding to a region of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
anti-P21-Activated Kinase 1 (PAK1) (AA 191-280) antibody
PAK1 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 4D1 unconjugated

anti-P21-Activated Kinase 1 (PAK1) (Center) antibody
PAK1 适用: 人, 大鼠, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (AA 252-501) antibody
PAK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (pThr212) antibody
PAK1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (AA 1-240) antibody
PAK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (pThr423) antibody
PAK1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB11381 unconjugated

anti-P21-Activated Kinase 1 (PAK1) (AA 401-430) antibody
PAK1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (AA 245-490) antibody
PAK1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (N-Term) antibody
PAK1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (pThr402) antibody
PAK1 适用: 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

This phospho specific polyclonal antibody was tested by ELISA and was found to bereactive with the phosphorylated form of the immunizing peptide and minimally reactivewith the non-phosphorylated form of the immunizing peptide. Although not tested, thisantibody is likely functional in Immunohistochemistry, Immunoblotting, andImmunoprecipitation. Lysates from Jurkat cells or PAK transfected cells may be used as a

限制

仅限研究用
浓度

1.0 mg/mL (by UV absorbance at 280 nm)

缓冲液

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01 % (w/v) Sodium Azide as preservative.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 2-8 °C.
抗原

PAK1 (P21-Activated Kinase 1 (PAK1))

别名

PAK1

背景

The p21-activated kinases (PAKs) are a family of multifunctional serine/threonine kinases involved in a variety of cell functions including stress response, apoptosis and regulation of cell motility and tumor metastasis. Mammalian PAKs are called 1, 2, 3 or α, γ, β respectively. PAKs are part of a large family of kinases where the catalytic domain of the kinase is related to Ste20 kinase of S. cerevisiae. Pak activity is regulated by specific binding of GTP-bound Rac and cdc42 GTPases and also by sphingosine and related lipids. PAK1 activation is induced by a variety of growth factors and G-protein-coupled receptors, Fc receptors, and integrins. This antibody is specific for the phosphorylated form of PAK 1/2/3. The selected peptide sequence used to generate the polyclonal antibody is common to all human PAKs.Synonyms: Alpha-PAK, Beta-PAK, Gamma-PAK, OPHN3, Oligophrenin-3, PAK 1, PAK 2, PAK 3, PAK alpha, PAK beta, PAK gamma, PAK-1, PAK-2, PAK-3, PAK65, Serine/threonine-protein kinase PAK 1, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase PAK 3, p21-activated kinase 1, p21-activated kinase 2, p21-activated kinase 3, p58, p65-PAK

基因ID

5058

NCBI登录号

NP_001122092

UniProt

Q13153

途径

MAPK Pathway, RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Embryonic Body Morphogenesis