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PAK1 抗体 (pThr423)

Cited in 2+ publications. The 兔多克隆 anti-PAK1 antibody (Clone RB11381) (ABIN389799) specifically detects PAK1 in WB 和 IF. The antibody is reactive with 人 samples.

Western blot analysis of lysates from Hela cell line, untreated or treated with EGF(1 μg/mL, 10 min), using Phospho-K1 Antibody (upper) or Beta-actin (lower). (PAK1 抗体 (pThr423))

Confocal immunofluorescent analysis of Phospho-K1-p Antibody (ABIN389799 and ABIN2839695) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (PAK1 抗体 (pThr423))

Dot blot analysis of anti-K1-p Phospho-specific b (ABIN389799 and ABIN2839695) on nitrocellulose membrane. (PAK1 抗体 (pThr423))

3 images

(2 references)

产品编号 ABIN389799

发货至: 中国

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Quick Overview for PAK1 抗体 (pThr423) (ABIN389799)

抗原

See all PAK1 抗体

PAK1 (P21-Activated Kinase 1 (PAK1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This PAK1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

RB11381

Discover our top product PAK1 Primary Antibody

抗原表位
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pThr423

预测反应

B, M, Rat, Rb, X

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This PAK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T423 of human PAK1.

亚型

Ig Fraction
anti-P21-Activated Kinase 1 (PAK1) (AA 191-280) antibody
PAK1 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 4D1 unconjugated

anti-P21-Activated Kinase 1 (PAK1) (Center) antibody
PAK1 适用: 人, 大鼠, 小鼠 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (AA 252-501) antibody
PAK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (pThr212) antibody
PAK1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (AA 1-240) antibody
PAK1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (AA 401-430) antibody
PAK1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (AA 245-490) antibody
PAK1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (N-Term) antibody
PAK1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (pThr402) antibody
PAK1 适用: 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-P21-Activated Kinase 1 (PAK1) (Ser204) antibody
PAK1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:500. IF: 1:10~50. DB: 1:500

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Zhang, Li, Liu, Cao, Chen, Liu, Wang, Du, Weng, Ma: "p21-activated kinase 1 activity is required for histone H3 Ser10 phosphorylation and chromatin condensation in mouse oocyte meiosis." in: Reproduction, fertility, and development, Vol. 29, Issue 7, pp. 1287-1296, (2018) (PubMed).

El-Baba, Mahadevan, Fahlbusch, S, Rau, Gali-Muhtasib, Schneider-Stock: "Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer." in: Molecular cancer, Vol. 13, pp. 201, (2014) (PubMed).
抗原

PAK1 (P21-Activated Kinase 1 (PAK1))

别名

PAK1

背景

PAK proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.

分子量

60647

基因ID

5058

NCBI登录号

NP_001122092, NP_002567

UniProt

Q13153

途径

MAPK Pathway, RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Embryonic Body Morphogenesis