STAT6 抗体 (pTyr641) (Alexa Fluor 647)
(4 references)-
- 抗原 See all STAT6 抗体
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
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抗原表位
- pTyr641
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适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This STAT6 antibody is conjugated to Alexa Fluor 647
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应用范围
- Intracellular Staining (ICS)
- 品牌
- BD Phosflow™
- 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Phosphorylated Mouse STAT6 (Y641) Peptide
- 克隆位点
- J71-773-58-11
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product STAT6 Primary Antibody
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anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 694-801) antibody
STAT6 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 6C10 unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pThr645) antibodySTAT6 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 614-663) antibodySTAT6 适用: 人, 小鼠, 大鼠, 犬, Cow, 猴, 兔, Pig, 马, 豚鼠, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 1-180) antibodySTAT6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (C-Term) antibodySTAT6 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pTyr641) antibodySTAT6 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) antibodySTAT6 适用: 人, 小鼠 WB, IHC, IHC (p), FACS, IF (cc) 宿主: 兔 Monoclonal 9A7 unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 557-841) antibodySTAT6 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 1-847) antibodySTAT6 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 1-847) antibodySTAT6 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Note: For flow cytometric analysis of human cells, Alexa Fluor® 647 Mouse Anti-Hunan Stat6 (pY641) mAb (clone 18) (Cat. No. 612601) is recommended.
- 样本量
- 20 μL
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated to Alexa Fluor® 647 under optimum conditions, and unreacted Alexa Fluor® 647 was removed.
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: "The phenotype of murine wound macrophages." in: Journal of leukocyte biology, Vol. 87, Issue 1, pp. 59-67, (2010) (PubMed).
: "Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus." in: PLoS ONE, Vol. 4, Issue 8, pp. e6756, (2009) (PubMed).
: "Requirements for interleukin-4-induced gene expression and functional characterization of Stat6." in: Molecular and cellular biology, Vol. 16, Issue 10, pp. 5811-20, (1996) (PubMed).
: "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis." in: Molecular and cellular biology, Vol. 15, Issue 6, pp. 3336-43, (1995) (PubMed).
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: "The phenotype of murine wound macrophages." in: Journal of leukocyte biology, Vol. 87, Issue 1, pp. 59-67, (2010) (PubMed).
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- 抗原
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
- 别名
- Stat6 (STAT6 产品)
- 别名
- D12S1644 antibody, IL-4-STAT antibody, STAT6B antibody, STAT6C antibody, signal transducer and activator of transcription 6 antibody, signal transducer and activator of transcription 6-like antibody, STAT6 antibody, Stat6 antibody, LOC100859543 antibody
- 背景
- STATs (signal transducers and activators of transcription) are critical mediators of the biologic activity of cytokines including Interleukins (IL) 2-5, IL-7, IL-15, GM-CSF, erythropoietin and growth hormone. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of STATs by tyrosine phosphorylation. Active STATs then move to the nucleus to promote transcription of cytokine-inducible genes. Seven STAT proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat6 plays an important role in signaling pathways that lead to the differentiation of T helper type 2 (Th2) cells from uncommitted CD4 T cell precursors. Moreover, IL-4, secreted by activated T lymphocytes, basophils, and mast cells, induces specific gene expression via the induction of tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. The J71-773.58.11 antibody recognizes mouse Stat6 phosphorylated at Y641.
- 途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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