(3 references)-
- 抗原 See all LTBR 抗体
- LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))
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抗原表位
- AA 31-221, Cysteine-Rich Domain
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This LTBR antibody is un-conjugated
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应用范围
- Functional Studies (Func)
- 特异性
- Recognizes mouse LTbetaR.
- 交叉反应
- 小鼠
- 纯化方法
- Purified from concentrated hybridoma tissue culture supernatant.
- 纯度
- >95 % (SDS-PAGE)
- 免疫原
- Recombinant mouse LTbetaR (cysteine-rich region) (aa 31-221).
- 克隆位点
- 3C8
- 亚型
- IgG1
- Top Product
- Discover our top product LTBR Primary Antibody
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anti-Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 66-215) antibody
LTBR 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 31-227) antibodyLTBR 适用: 人, 小鼠 WB, ELISA, FACS, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 1D1C5C8 unconjugated
anti-Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 128-395) antibodyLTBR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (N-Term) antibodyLTBR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 31-224) antibodyLTBR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 31-227) antibodyLTBR 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 66-215) antibodyLTBR 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (AA 351-435) antibodyLTBR 适用: 人, 小鼠 WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) (N-Term) antibodyLTBR 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) antibodyLTBR 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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The monoclonal antibody to mouse LTbetaR is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-kappaB family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kappaB2 pathway. For use as an agonist the MAb to LTbetaR is added to cell cultures at 2μg/ml. For in vivo use, mice are injected intraperitoneally with 50μg of agonistic MAb to LTbetaR in sterile phosphate saline buffer.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- In PBS containing 10 % glycerol and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. - 有效期
- 12 months
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: "LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 9, pp. 5439-45, (2009) (PubMed).
: "Specific remodeling of splenic architecture by cytomegalovirus." in: PLoS pathogens, Vol. 2, Issue 3, pp. e16, (2006) (PubMed).
: "A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 7217-25, (2005) (PubMed).
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: "LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 9, pp. 5439-45, (2009) (PubMed).
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- 抗原
- LTBR (Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR))
- 别名
- LTbetaR (LTBR 产品)
- 别名
- AI256028 antibody, CD18 antibody, LTbetaR antibody, Ltar antibody, TNF-R-III antibody, TNFCR antibody, TNFR-RP antibody, TNFR2-RP antibody, TNFRrp antibody, Tnfbr antibody, Tnfrsf3 antibody, D12S370 antibody, LT-BETA-R antibody, TNFR3 antibody, TNFRSF3 antibody, lymphotoxin beta receptor antibody, lymphotoxin B receptor antibody, Ltbr antibody, LTBR antibody
- 背景
- The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
- UniProt
- P50284
- 途径
- NF-kappaB Signaling
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