Vang-like protein 1 (VANGL1), also called Loop-tail protein 2 homolog (LPP2), is encoded by the VANGL1 gene, This gene contains 8 exons and it maps to chromosome 1p13 . The VANGL1 protein is a 524-amino acid , 65KD protein, which has 4 transmembrane domains and a C-terminal ser/thr-x-val motif. Yagyu et al. (2002) found that downregulation of VANGL1 expression suppressed growth of a human hepatoma cell line. Kalabis et al. (2006) found that VANGL1 overexpression enhanced this migration and wound closure in cultured cells.