FHL2 抗体
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- 抗原 See all FHL2 抗体
- FHL2 (Four and A Half LIM Domains 2 (FHL2))
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适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FHL2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- The monoclonal antibody F4B2-B11 reacts specifically with the LIM-only protein FHL2. It recognizes the N-terminal Zn-Finger motif, it does not cross react in Western Blot with the FHL1 and FHL3 proteins.
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
- 纯化方法
- Protein G
- 克隆位点
- F4B2-B11
- 亚型
- IgG1
- Top Product
- Discover our top product FHL2 Primary Antibody
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anti-Four and A Half LIM Domains 2 (FHL2) (AA 1-279) antibody
FHL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) antibodyFHL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (AA 1-279) antibodyFHL2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G3-1A5 unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (AA 112-233) antibodyFHL2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (AA 199-248) antibodyFHL2 适用: 人, 小鼠, 大鼠, 犬, 马, 斑马鱼, 猴, Bat, Hamster, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) antibodyFHL2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (C-Term) antibodyFHL2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) antibodyFHL2 适用: 人, 小鼠 WB, IHC (p), IP 宿主: 小鼠 Monoclonal 31-10-34 unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (C-Term) antibodyVerified FHL2 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (AA 182-231) antibodyFHL2 适用: 人, Cow, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.1 mg/mL
- 缓冲液
- PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store at 2 - 8 °C.
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- 抗原
- FHL2 (Four and A Half LIM Domains 2 (FHL2))
- 别名
- FHL2 / SLIM3 (FHL2 产品)
- 别名
- AAG11 antibody, DRAL antibody, FHL-2 antibody, SLIM-3 antibody, SLIM3 antibody, C76204 antibody, FHL2 antibody, zgc:92428 antibody, zgc:103466 antibody, four and a half LIM domains 2 antibody, four and a half LIM domains 2a antibody, four and a half LIM domains 2b antibody, FHL2 antibody, Fhl2 antibody, fhl2 antibody, fhl2a antibody, fhl2b antibody
- 背景
- Five proteins share the same structural organization and a high degree of sequence homology in this group: four and a half LIM domain protein (FHL) 1, FHL2, FHL3, FHL4, and activator of cAMP-responsive element (CRE) modulator (CREM) in testis (ACT). LIM domains are constituted by a conserved cysteine- and histidine-rich structure shaped in two repeated zinc fingers first identified in the proteins encoded by the Lin-11, Isl-1, and Mec-3 genes. The LIM domain has been shown to function as a protein-protein interaction domain, and has often been described in association with other functional protein motifs, such as homeobox and kinase domains. FHL2 seems to be a promiscuous coactivator because it modulates the activity of the androgen receptor, CRE-binding protein (CREB), and WT1, although some degree of specificity is present because it is unable to stimulate CREM- and Sp1-dependent transcription. FHL2 expression was originally described to be restricted to the heart but it is inducible in other cell types. FHL2 shows specific interaction with beta-catenin, which requires the intact structure of all four LIM domains of FHL2 and the N-terminus plus the first armadillo repeat region of beta-catenin. FHL2 is a muscle-specific repressor of LEF/TCF target genes and promotes myogenic differentiation by interacting with beta-catenin.Synonyms: DRAL, FHL-2, Four and a half LIM domains protein 2, LIM domain protein DRAL, SLIM 3, Skeletal muscle LIM-protein 3
- 基因ID
- 2274
- NCBI登录号
- NP_001034581
- UniProt
- Q14192
- 途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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