The antibody detects the CD8 Molecule, expressed as a heterodimer of CD8a (32-34 kDa)and CD8b (32-34 kDa) glycoproteins. Clone MCD8 is commonly used in routine immunophenotyping, the determination of CD4/CD8 ratios in HIV/AIDS patients and aids in the identification of T cell leukemias (common T-ALL or mature T-ALL)s. MCD8 also distinguishes between chronic B and T cell lymphoid leukemias. Testing by flow cytometry using a 'lyse-wash' method on whole blood from healthy donors showed the following values expressed in terms of % of the total lymphocyte count: Product code: AM39011RP-N (anti-CD8 PE) n: 10 Mean % positive: 31,53 S.D.: 4,58 % CV: 14,52
CD8 acts as a co-receptor with the TcR in recognizing antigens presented by MHC Class I and plays a role in the T cell-mediated immune response. The CD8 antigen is present on most tymocytes, T cytotoxic/suppressor cells and a subpopulation of NK cells.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2