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CD5 抗体 (PE)

CD5 适用: 人 FACS, IF 宿主: 小鼠 Monoclonal MCD5 PE
产品编号 ABIN1106441
发货至: 中国
  • 抗原 See all CD5 抗体
    CD5
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    小鼠
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    单克隆
    标记
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    This CD5 antibody is conjugated to PE
    应用范围
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    Flow Cytometry (FACS), Immunofluorescence (IF)
    特异性
    MCD5 recognizes a 67 kDa antigen on human T cells. Other species not tested. Testing by flow cytometry using a 'lyse-wash' method on whole blood from healthy donors showed the following values expressed in terms of % of the total lymphocyte count: Product code: AM39009RP-N (anti-CD5 PE) Mean % positive: 73,32 S.D.: 5,58 % CV: 7,61
    纯化方法
    Affinity chromatography
    克隆位点
    MCD5
    亚型
    IgG2b
    Top Product
    Discover our top product CD5 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C. This product is photosensitive and should be protected from light.
  • 抗原
    CD5
    别名
    CD5 (CD5 产品)
    别名
    CD5 antibody, Ly-1 antibody, Ly-12 antibody, Ly-A antibody, Lyt-1 antibody, LEU1 antibody, T1 antibody, CD5 molecule antibody, CD5 antigen antibody, CD5 molecule like antibody, Cd5 molecule antibody, CD5 antibody, Cd5 antibody, CD5L antibody
    背景
    CD5 appears to be a relatively late marker during B cell differentiation. CD5 expression is thought to be absent on surface Ig negative B-lineage cells but appears on IgM+ cells in both fetal liver and bone marrow. It co-precipitates with the T cell receptor and, in particular with Lck. A role for CD5 in signal transduction is postulated based on stimulatory effects of CD5 monoclonal antibodies. CD5 antigen is phosphorylated on tyrosine residues on T cell activation. There is evidence that CD5 plays a role in thymocyte selection, as well as a role in cell-cell recognition. Recently CD5 on B cells has been shown to be an endogenous ligand selective for B-cell surface IgFR (framework region) sequences. Interaction of surface Ig with CD5, other endogenous antigens or (in mucosal sites) exogenous superantigens can provide B cells with continual stimulation and might prevent their elimination from the immune system. In addition, B cell superantigens, e.g. Staphylococcus aureus Cowan strain 1, may contribute to the pathogenesis of autoimmune diseases and malignancies.Synonyms: CD5, LEU1, Lymphocyte antigen T1/Leu-1, T-cell surface glycoprotein CD5
    基因ID
    921
    NCBI登录号
    NP_055022
    UniProt
    P06127
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