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RAGE 抗体 (AA 23-342)

Name: RAGE 抗体 (AA 23-342)
SKU: ABIN1045202
Availability: OutOfStock

AGER 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

产品编号 ABIN1045202

发货至: 中国

Datasheet as PDF

抗原 See all RAGE (AGER) 抗体

RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
抗原表位
19

16

16

11

9

9

8

7

4

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 23-342
适用
137

79

61

7

5

4

3

3

2

2

1
人
宿主
130

10

4

2

1
兔
Compatible Secondaries
克隆类型
125

21

1
多克隆
标记
65

11

10

9

8

5

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1
This RAGE antibody is un-conjugated
应用范围
119

63

48

32

27

26

21

11

8

7

7

3

2

1

1

1
Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

交叉反应

人

纯化方法

>95%, Protein G purified

免疫原

Recombinant Human Advanced glycosylation end product-specific receptor protein (23-342AA)

亚型

IgG

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AGER 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-404) antibody
AGER 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 151-250) antibody
AGER 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IP, IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-274) antibody
AGER 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-404) antibody
AGER 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C1 unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-120), (N-Term) antibody
AGER 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 76-104) antibody
AGER 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) antibody
AGER 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) antibody (Cy3)
AGER 适用: 人, Cow WB, IHC, ELISA, IHC (p), ICC 宿主: 小鼠 Monoclonal DD-A11 Cy3

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (N-Term) antibody
AGER 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马, Pig WB 宿主: 兔 Polyclonal unconjugated

应用备注

Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500,

限制

仅限研究用
状态

Liquid

缓冲液

Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

注意事项

Avoid freeze and thaw cycles.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

别名

AGER (AGER 产品)

别名

RAGE antibody, AGER antibody, advanced glycosylation end-product specific receptor antibody, advanced glycosylation end product-specific receptor antibody, MAPK/MAK/MRK overlapping kinase antibody, AGER antibody, Ager antibody, LOC719012 antibody

背景

Background: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling By similarity. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.
Aliases: Advanced glycosylation end product-specific receptor antibody, Ager antibody, DAMA 358M23.4 antibody, MGC2235 antibody, MGC22357 antibody, RAGE_HUMAN antibody, Receptor for advanced glycation end products antibody, Receptor for advanced glycosylation end products antibody

UniProt

Q15109

途径

Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins