anti-WW and C2 Domain Containing 1 (WWC1) 抗体

The protein encoded by WWC1 is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. 再加上,我们可以发WW and C2 Domain Containing 1 试剂盒 (12)WW and C2 Domain Containing 1 蛋白 (9)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
WWC1 23286 Q8IX03
WWC1 211652 Q5SXA9
WWC1    
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Showing 10 out of 56 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-WWC1 Antibody Titration: 1.0 ug/ml Positive Control: PANC1 Whole Cell 100 μL Log in to see 2至3个工作日
$319.00
详细
非结合性 WB WWC1 Antibody (N-term) (ABIN654697) western blot analysis in ZR-75-1 cell line lysates (35 µg/lane). This demonstrates the WWC1 antibody detected the WWC1 protein (arrow). 400 μL Log in to see 10至11个工作日
$385.00
详细
非结合性 EIA, WB WWC1 Antibody (N-term) western blot analysis in ZR-75-1 cell line lysates (35 µg/lane). This demonstrates the WWC1 antibody detected the WWC1 protein (arrow). 0.4 mL Log in to see 6至8个工作日
$484.00
详细
非结合性 ICC, IF, IHC, IHC (p), WB Western Blot: KIBRA Antibody [NBP1-92052] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunocytochemistry/Immunofluorescence: KIBRA Antibody [NBP1-92052] - Staining of human cell line A-431 shows positivity in golgi apparatus. 0.1 mL Log in to see 10至13个工作日
$494.38
详细
非结合性 ELISA, WB Western blot analysis of Phospho-KIBRA(Ser947) in lysates of 293?, using Phospho-KIBRA(Ser947) Antibody(ABIN6267843). 100 μL Log in to see 11至12个工作日
$450.00
详细
小鼠 非结合性 WB 100 μL Log in to see 11至14个工作日
$507.83
详细
非结合性 ELISA, WB Western blot analysis of KIBRA in lysates of 293, using KIBRA Antibody(ABIN6268259). 100 μL Log in to see 11至12个工作日
$450.00
详细
非结合性 ELISA, IF, IHC, IHC (p), WB Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11至14个工作日
$484.00
详细
小鼠 非结合性 ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. DAB staining on IHC-P; Samples: Mouse Pancreas Tissue 100 μg Log in to see 13至16个工作日
$396.00
详细
非结合性 IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-KIBRA Polyclonal Antibody, Unconjugated (ABIN1387477) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat kidney labeled with Anti-KIBRA Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3至7个工作日
$317.90
详细

引用最多的anti-WW and C2 Domain Containing 1 抗体

  1. Human Polyclonal WWC1 Primary Antibody for ICC, IF - ABIN4328780 : Tanaka, Osada, Fujii, Fukatsu, Hida, Horio, Kondo, Sato, Hasegawa, Tsujimura, Sekido: LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade. in Oncogene 2015 (PubMed)

更多抗WW and C2 Domain Containing 1的相互作用对抗体

Fruit Fly (Drosophila melanogaster) WW and C2 Domain Containing 1 (WWC1) interaction partners

  1. elevated expression of Par3 promotes PCa metastasis via KIBRA sequestration-mediated inactivation of the Hippo pathway to upregulate expression of pro-metastatic genes.

  2. Merlin and Kibra activate Hippo signaling in parallel to Expanded at a spatially distinct cellular domain, the medial apical cortex.

  3. Kibra, a binding partner of Pez, stabilizes Pez via WW-PY/PPxY interaction.

  4. Kibra regulates starvation-induced autophagy downstream of aPKC.

  5. In the human brain, KIBRA is mainly expressed in hippocampus and interacts with proteins involved in long-term potentiation and synaptic plasticity and effect memory in aged.

  6. The result reveals role for Kibra in neuronal specification and maintenance and show that the Hippo pathway is reimplemented for sensory neuron fate by combining canonical and noncanonical regulatory steps.

  7. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.

  8. Kibra is a regulator of the Salvador/Warts/Hippo signaling network.

  9. Kibra predominantly acts in the Merlin branch upstream of the core kinase cascade to regulate Hippo signaling.

Human WW and C2 Domain Containing 1 (WWC1) interaction partners

  1. MiR-21 suppressed the Hippo signaling pathway and promoted the progression of lung adenocarcinoma through targeting KIBRA.

  2. These results indicate that KIBRA C2 domain association with membranes is calcium-independent and involves distinctive C2 domain-membrane relative orientations.

  3. Our findings suggest that the T-allele of KIBRA rs17070145 supports recollection based episodic memory retrieval and contributes to memory accuracy in a gender dependent manner.

  4. Overall low-KIBRA expression has an independent effect on the recurrence-free survival (RFS) and predicts the RFS outcome of luminal breast cancer patients who received endocrine therapy and breast cancer patients who received chemotherapy.

  5. KIBRA rs17070145 is associated with accelerated cognitive decline in APOE epsilon4-positive cognitively normal adults with high Abeta-amyloid burden.

  6. Data (including data from studies in knockout mice) suggest that KIBRA plays important role in regulating HPO activity, YAP signaling, and actin cytoskeletal dynamics in podocytes; expression of KIBRA and YAP plus phosphorylation of YAP are up-regulated in glomeruli of patients with focal segmental glomerulosclerosis. (KIBRA = kidney/brain protein-KIBRA; HPO = hepatopoietin protein; YAP = Yes associated protein-1)

  7. the overall data in the present meta-analysis revealed a significant association of KIBRA polymorphism rs17070145 and risk of Alzheimer disease. [meta-analysis]

  8. the study indicated that loss of WWC1 may contribute to podocyte apoptosis by inducing nuclear relocation of dendrin protein, which provided novel insight into the molecular events in podocyte apoptosis.

  9. that APOE and KIBRA have region-dependent additive and epistatic interactions on brain connectivity in healthy young adults

  10. In younger adults, no effects of KIBRA were found

  11. Data show that promoter methylation is a major mechanism involved in KIBRA expression regulation. KIBRA expression levels are reduced in clear cell renal cell carcinoma (ccRCC) and alterations in the balance of KIBRA/SP1 binding by promoter methylation may be involved in the onset and/or progression of ccRCC.

  12. our results suggest that the effect of the WWC1 rs17070145 polymorphism on memory performance and Alzheimer's disease might be due to a differential regulation of the MAPK signaling, a key pathway involved in memory and learning processes

  13. we report for the first time that CRB3 acts as an upstream regulator of the Hippo pathway to regulate contact inhibition by recruiting other Hippo molecules, such as Kibra and/or FRMD6, in mammary epithelial cells.

  14. Ability to navigate in the wilderness benefits from episodic memory (KIBRA).

  15. Study identifies four likely Tourette disorder risk genes with multiple de novo damaging variants in unrelated probands: WWC1 (WW and C2 domain containing 1), CELSR3 (Cadherin EGF LAG seven-pass G-type receptor 3), NIPBL (Nipped-B-like), and FN1 (fibronectin 1).

  16. study provides a mechanistic link between aberrant tau acetylation, KIBRA deficiency, and dementia in Alzheimer's disease

  17. show that KIBRA is overexpressed in human prostate tumors. Our studies uncover unexpected results and identify KIBRA as a tumor promoter in prostate cancer

  18. No significant differences in allelic or gene frequency distribution of KIBRA SNP rs17070145 were observed between schizophrenic and healthy control groups.

  19. WWC1 variants are involved in AMPA receptor trafficking and neuronal plasticity, which are associated with cognitive impairment and schizophrenia susceptibility.

  20. Study observed a trend for a better memory performance and significantly higher volumes and better microstructural integrity in the subfields comprising the CA2/3 and CA4/DG of the hippocampus in KIBRA T-allele carriers compared with non-T-carriers

Mouse (Murine) WW and C2 Domain Containing 1 (WWC1) interaction partners

  1. Study illustrated the expression at the protein level of a memory-related protein-KIBRA in the intestine of APP/PS1 Alzheimer disease mouse model. Protein levels of KIBRA significantly increased in the jejunal myenteric plexus of APP/PS1 mice.

  2. study provides a mechanistic link between aberrant tau acetylation, KIBRA deficiency, and dementia in Alzheimer's disease

  3. KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKMzeta

  4. These results indicate that KIBRA regulates higher brain function by regulating AMPAR trafficking and synaptic plasticity.

  5. KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif

  6. KIBRA functions in memory performance via interaction with PKMzeta.

WW and C2 Domain Containing 1 (WWC1) 抗原简介

蛋白简介

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with WWC1

  • CG33967 gene product from transcript CG33967-RB (kibra) 抗体
  • WW and C2 domain containing 1 (WWC1) 抗体
  • WW, C2 and coiled-coil domain containing 1 (Wwc1) 抗体
  • AA408228 抗体
  • AU017197 抗体
  • BC037006 抗体
  • CG7552 抗体
  • CG12600 抗体
  • CG33967 抗体
  • Dmel\\CG33967 抗体
  • HBEBP3 抗体
  • HBEBP36 抗体
  • kib 抗体
  • KIBRA 抗体
  • l(3)02404 抗体
  • l(3)j5C3 抗体
  • l(3)neo42 抗体
  • mKIAA0869 抗体
  • ORE-2 抗体
  • RE26350 抗体

Protein level used designations for WWC1

CG33967-PA , kibra-PA , lethal (3) neo42 , HBeAg-binding protein 3 , WW, C2 and coiled-coil domain containing 1 , kidney and brain protein , protein KIBRA , protein WWC1 , WW domain-containing protein 1

GENE ID SPECIES
41783 Drosophila melanogaster
23286 Homo sapiens
211652 Mus musculus
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