anti-WNK Lysine Deficient Protein Kinase 4 (WNK4) 抗体

WNK4 encodes a member of the WNK family of serine-threonine protein kinases. 再加上,我们可以发WNK4 蛋白 (6)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
WNK4 65266 Q96J92
WNK4 69847 Q80UE6
WNK4 287715 Q7TPK6
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非结合性 EM, IHC, IHC (fro), IHC (p), WB Detection of WNK4 in mouse kidney lysate using ABIN153223. Western Blot: WNK4 Antibody [ABIN153223] - Western Blot Image of anti-WNK4. Whole cell protein from Hek293 was separated on a 7.5% gel by SDS-PAGE, transferred to PVDF membrane and blocked in 5% non-fat milk in TBST. The membrane was probed with 2.0 ug/ml anti-WNK4 in 1% milk and detected with an anti-rabbit HRP secondary antibody using chemiluminescence 0.1 mL Log in to see 7至9个工作日
$446.35
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非结合性 IF (p), IHC (p), WB Mouse eye lysates probed with WNK4 Polyclonal Antibody, Unconjugated  at 1:300 dilution and 4˚C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37˚C. 100 μL Log in to see 3至7个工作日
$317.90
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PE IHC, ELISA   200 μL Log in to see 11至14个工作日
$1,013.83
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APC ELISA   200 μL Log in to see 11至14个工作日
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APC IHC, ELISA   200 μL Log in to see 11至14个工作日
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Alkaline Phosphatase (AP) IHC, ELISA   200 μL Log in to see 11至14个工作日
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Alkaline Phosphatase (AP) ELISA   200 μL Log in to see 11至14个工作日
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FITC IHC, ELISA   200 μL Log in to see 11至14个工作日
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FITC ELISA   200 μL Log in to see 11至14个工作日
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PE ELISA   200 μL Log in to see 11至14个工作日
$1,013.83
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引用最多的anti-WNK4 抗体

  1. Human Polyclonal WNK4 Primary Antibody for EM, IHC - ABIN153223 : Wilson, Disse-Nicodème, Choate, Ishikawa, Nelson-Williams, Desitter, Gunel, Milford, Lipkin, Achard, Feely, Dussol, Berland, Unwin, Mayan, Simon, Farfel, Jeunemaitre, Lifton: Human hypertension caused by mutations in WNK kinases. in Science (New York, N.Y.) 2001 (PubMed)
    Show all 11 Pubmed References

  2. Polyclonal WNK4 Primary Antibody for WB - ABIN540240 : Kahle, Gimenez, Hassan, Wilson, Wong, Forbush, Aronson, Lifton: WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Show all 2 Pubmed References

更多抗WNK4的相互作用对抗体

Human WNK Lysine Deficient Protein Kinase 4 (WNK4) interaction partners

  1. tacrolimus increases levels of KLHL3(S433-P), resulting in increased levels of WNK4, phosphorylated SPAK, and Na-Cl cotransporter.These findings demonstrate that KLHL3(S433-P) is a calcineurin substrate and implicate increased KLHL3 phosphorylation in tacrolimus-induced pathologies.

  2. 5 WNK4 sites (S47, S64, S1169, S1180, S1196) are phosphorylated downstream of AngII signaling in cultured cells and in vitro by PKC and PKA. Phosphorylation at S64 and S1196 promoted phosphorylation of the WNK4 kinase T-loop at S332 (required for kinase activation) and increased phosphorylation of SPAK. Volume depletion induced phosphorylation of these sites in vivo, predominantly in the distal convoluted tubule.

  3. Modulation of WNK4 activity by [Cl]i can account for its dual role on the NCC, and this has important physiological implications regarding the regulation of extracellular potassium concentration.

  4. This study provides substantial new insights into the role of phosphorylation of KLHL3 in regulating the interaction with WNK4

  5. The distribution of allele frequency and genotype of WNK4 gene Ala589Ser polymorphism showed significant differences between essential hypertension subjects, with or without type 2 diabetes mellitus, and normotensive subjects.

  6. Data indicate that WNK lysine deficient protein kinase 4 protein (WNK4) was degraded not only by proteasomes but also by atypical protein kinase C scaffold protein p62 (p62)-kelch-like 3 protein (KLHL3)-mediated selective autophagy.

  7. this meta-analysis suggested that WNK4 G1155942T and C6749T gene polymorphisms may contribute to the susceptibility and development of hypertension.

  8. Akt and PKA phosphorylated KLHL3 at S433, and phosphorylation of KLHL3 by PKA inhibited WNK4 degradation.

  9. WNK4 is a substrate of SFKs and the association of c-Src and PTP-1D with WNK4 at Tyr(1092) and Tyr(1143) plays an important role in modulating the inhibitory effect of WNK4 on ROMK

  10. WNK4 inhibits SNARE formation of syntaxin 13 with VAMP2.

  11. Regulation of WNK4 by CUL3 and its relationship to blood pressure regulation and electrolyte homeostasis. [Review]

  12. WNK4 inhibits Large-conductance, Ca(2 )-activated K( ) channel activity, in part, by increasing channel degradation through an ubiquitin-dependent pathway.

  13. analysis of how mutations of KLHL3 show less ability to ubiquitinate WNK4 because of KLHL3's low stability and/or decreased binding to CUL3 or WNK4

  14. WNK4 inhibits ENaC channel activity independently of Nedd4-2-mediated ENaC ubiquitination.

  15. KLHL3 is a substrate adaptor for WNK4 in a ubiquitin E3 ligase complex

  16. The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

  17. The Exon 8 G1155942T polymorphism in WNK4 gene was associated with hypertension in the Kazakhs ethnic group in Xinjiang, and the T allele might be the risk factor for essential hypertension.

  18. R1185C mutation disrupts a CaM binding site at the WNK4 COOH-terminal region and alters the phosphorylation of WNK4 by SGK1.

  19. hypertension associated polymorphisms in WNK1 and WNK4 may not be predictors for antihypertensive response to diuretics.

  20. Data show that K1169E lost its inhibitory effect on NCC surface expression compared to wild-type WNK4 when expressed in HEK293 cells, while it did not change NCC total protein expression.

Mouse (Murine) WNK Lysine Deficient Protein Kinase 4 (WNK4) interaction partners

  1. C-terminally truncated WNK4 constructs are more active than full-length WNK4, as long as they contain the C-terminal SPAK-binding site.

  2. reduced age-dependent weight gain of WNK1 TG mice seems to be related with the decreased Kir6.2 expression via WNK1- and WNK4-regulated protein stability of Kir6.2.

  3. WNK4 protein affected the DNA-binding ability of C/EBPbeta and thereby reduced PPARgamma expression. In the WNK4(-/-) mice, PPARgamma and C/EBPalpha expression were decreased in adipose tissues, and the mice exhibited partial resistance to high-fat diet-induced adiposity.

  4. However, phosphorylation of SPAK and NCC at distal convoluted tubules were almost completely absent even in WNK4(-/-)KLHL3(R528H/R528H) mice. In conclusion, increased WNK1 was unable to compensate for WNK4 deficiency and phosphorylate the NCC, indicating that WNK4 is indispensable for the onset of PHAII.

  5. ENaC and ROMK channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4(PHAII)-induced inhibition of ENaC and ROMK may contribute to the suppression of K(+) secretion in the tubules.

  6. Accordingly, medullary WNK4 protein levels were significantly increased in the kidneys of KLHL2(-/-) mice. KLHL2 is indeed a physiological regulator of WNK4 in vivo; however, its function might be different from that of KLHL3 because KLHL2 mainly localized in medulla.

  7. The results indicate that quite modest changes in dietary K intake affect plasma [K] and thiazide-sensitive NaCl cotransporter activity. These effects are mediated largely by WNK4, as this kinase exhibits unique Cl-sensitive properties.

  8. the increased NCC expression and activation is present in CMA which is highly associated with the enhanced WNK4-SPAK signal pathway using WNK4-/- and SPAK-/- mice.

  9. increased protein expression levels of WNK1 and WNK4 kinases cause PHAII by KLHL3 R528H mutation due to impaired KLHL3-Cullin3-mediated ubiquitination.

  10. KLHL3 is phosphorylated at serine 433 in the Kelch domain (a site frequently mutated in hypertension with hyperkalemia) by protein kinase C in cultured cells and that this phosphorylation prevents WNK4 binding and degradation.

  11. WNK4 is the major positive regulator of NCC in the kidneys.

  12. WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.

  13. in addition to SPAK and OSR1, WNK4 is able to anchor itself to the N-terminal domain of NKCC1 and to promote cotransporter activation.

  14. SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.

  15. Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.

  16. data suggest that WNK4 inhibits NCC protein through activating the MAPK ERK1/2 signaling pathway.

  17. these results suggest that these PHAII-causing mutations disrupt a Ca(2+)-sensing mechanism around the acidic motif necessary for the regulation of WNK4 kinase activity by Ca(2+) ions.

  18. Immunolocalization of WNK4 in mouse kidney.

  19. Results clearly establish that PHAII caused by the WNK4 D561A mutation is dependent on the activation of the WNK-OSR1/SPAK-NCC cascade.

  20. beta(2)-adrenergic receptor stimulation led to decreased transcription of the gene encoding WNK4, a regulator of sodium reabsorption

WNK4 抗原简介

蛋白简介

This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.

Gene names and symbols associated with WNK4

  • WNK lysine deficient protein kinase 4 (WNK4) 抗体
  • WNK lysine deficient protein kinase 4 (Wnk4) 抗体
  • 2010002J11Rik 抗体
  • Ac2-059 抗体
  • Pha2b 抗体
  • Prkwnk4 抗体
  • WNK4 抗体

Protein level used designations for WNK4

WNK lysine deficient protein kinase 4 , protein kinase lysine-deficient 4 , protein kinase with no lysine 4 , serine/threonine-protein kinase WNK4 , protein kinase, lysine deficient 4 , WNK4 Ser/Thr kinase , protein kinase, lysine-deficient 4

GENE ID SPECIES
454699 Pan troglodytes
490959 Canis lupus familiaris
100139742 Bos taurus
100617641 Monodelphis domestica
65266 Homo sapiens
69847 Mus musculus
287715 Rattus norvegicus
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