WNK4 产品
(WNK Lysine Deficient Protein Kinase 4 (WNK4))
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This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009].
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Featured WNK4 Categories
Recommended WNK4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7169234
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB
Validations
- (2)
Cat. No.
ABIN528800
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB
Validations
- (2)
- (1)
Cat. No.
ABIN540240
Quantity
100 μL
Datasheet
Datasheet
Recommended WNK4 蛋白
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Reactivity
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Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569662
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1325354
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3096394
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our WNK4 Products
: "High frequency and wide range of human kidney papillary crystalline plugs." in: Urolithiasis, (2018) (PubMed).: "Role of nitric oxide and WNK-SPAK/OSR1-KCC2 signaling in daily changes in GABAergic inhibition in the rat dorsal raphe neurons." in: Neuropharmacology, Vol. 135, pp. 355-367, (2018) (PubMed).
: "WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 37, Issue 8, pp. 2780-2794, (2017) (PubMed).
: "Gender difference in kidney electrolyte transport. I. Role of AT1a receptor in thiazide-sensitive Na+-Cl- cotransporter activity and expression in male and female mice." in: American journal of physiology. Renal physiology, Vol. 313, Issue 2, pp. F505-F513, (2017) (PubMed).
: "FGF23 promotes renal calcium reabsorption through the TRPV5 channel." in: The EMBO journal, Vol. 33, Issue 3, pp. 229-46, (2014) (PubMed).
: "Immunolocalization of WNK4 in mouse kidney." in: Histochemistry and cell biology, Vol. 136, Issue 1, pp. 25-35, (2011) (PubMed).
: "Pathophysiological roles of WNK kinases in the kidney." in: Pflügers Archiv : European journal of physiology, Vol. 460, Issue 4, pp. 695-702, (2010) (PubMed).
: "WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction." in: The Journal of biological chemistry, Vol. 284, Issue 27, pp. 18471-80, (2009) (PubMed).
: "Regulation of blood pressure, the epithelial sodium channel (ENaC), and other key renal sodium transporters by chronic insulin infusion in rats." in: American journal of physiology. Renal physiology, Vol. 290, Issue 5, pp. F1055-64, (2006) (PubMed).
: "WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 7, pp. 2064-9, (2004) (PubMed).
Synonyms and alternative names related to WNK4
WNK lysine deficient protein kinase 4 (WNK4), WNK lysine deficient protein kinase 4 (Wnk4), 2010002J11Rik, Ac2-059, PHA2B, Pha2b, PRKWNK4, Prkwnk4, WNK4Protein level used designations for WNK4
- WNK lysine deficient protein kinase 4
- protein kinase lysine-deficient 4
- protein kinase with no lysine 4
- serine/threonine-protein kinase WNK4
- protein kinase, lysine deficient 4
- WNK4 Ser/Thr kinase
- protein kinase, lysine-deficient 4
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