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The protein encoded by MAFB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. 再加上，我们可以发MAFB 蛋白 (9)和数多这个蛋白质的别的产品。
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Human Polyclonal MAFB Primary Antibody for ICC, IF - ABIN4332354
Pasquali, Gaulton, Rodríguez-Seguí, Mularoni, Miguel-Escalada, Akerman, Tena, Morán, Gómez-Marín, van de Bunt, Ponsa-Cobas, Castro, Nammo, Cebola, García-Hurtado, Maestro, Pattou, Piemonti, Berney et al.: Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. ... in Nature genetics 2014
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Data suggest that SUMOylated MAFB promotes colorectal cancer tumorigenesis through cell cycle regulation.
these results demonstrate that MAFB critically determines the acquisition of the anti-inflammatory transcriptional and functional profiles of human macrophages
The present study demonstrated that miR (显示 MLXIP 抗体)-152 was downregulated in NPC (显示 NPC1 抗体) tissues and cell lines. In addition, miR (显示 MLXIP 抗体)-152 expression and MAFB knockdown inhibited cell proliferation, migration and invasion, and miR (显示 MLXIP 抗体)-152 suppressed the expression of MAFB at the mRNA and protein levels.
Epidermal differentiation gene regulatory networks are controlled by MAF (显示 MAF 抗体) and MAFB.
Loss of MAFB Function Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects.
Results indicate a hepatocellular carcinoma (HCC (显示 FAM126A 抗体)) regulatory pathway involving MafB transcription factor and cyclin D1 (显示 CCND1 抗体), the dysfunction of which drives proliferative character in HCC (显示 FAM126A 抗体).
DNMT3A (显示 DNMT3A 抗体) R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia (显示 BCL11A 抗体) blasts.
MAFB is a regulator and a marker of adipose tissue inflammation, a process that subsequently causes insulin (显示 INS 抗体) resistance
MAFB represents a unique signature and likely important regulator of the primate islet beta-cell.
The rs2902940A allele carriers in the MAFB conferred a decreased serum ApoAI level in controls and an increased risk of coronary artery disease and ischemic stroke.
Vegfc (显示 VEGFC 抗体) signaling increases mafba expression to control downstream transcription
MAFB localized in Leydig and Sertoli cells in testes at E18.5 while it localized in Leydig cells, Sertoli cells, and pachytene spermatocytes in adult testes. Examination revealed that MAFB-deficient testes developed normally by E18.5, and spermatogenesis was not disrupted in adult mice. MAFB MAFB might be critical for phagocytosis activity of Sertoli cells.
MafB controls endothelial sprouting in vitro and in vivo in postnatal retinal angiogenesis.
Macrophage-specific inhibition of MafB may destabilize atherosclerotic plaques in advanced lesions
a protective role of oxLDL-associated LPS (显示 TLR4 抗体) on beta-cell function during hyperlipidemia by inducing miR (显示 MLXIP 抗体)-155-5p, which prevents the upregulation of MafB and beta-to-alpha-cell reprogramming.
Increased mafB at the common myeloid progenitor stage steers their lineage away from the megakaryocyte erythrocyte progenitor production and drives the terminal fate of these progenitors to form macrophages vs. dendritic cells, causing anemia, monocytosis, and dendritic cell loss. It is a transcriptional activator of M-CSFR (显示 CSF1R 抗体) and a repressor of transferrin (显示 Tf 抗体) receptors, promoting macrophages and plasmacytoid dendritic cells.
An elevation of MSR1 (显示 MSR1 抗体) levels in infiltrating myeloid cells observed 3 d after experimental stroke was dependent on the transcription factor Mafb. Mafb deficiency in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke.
a Mafb-driven Cre strain was generated to determine whether any dendritic cells (DCs) identified by Zbtb46 (显示 ZNF340 抗体)-green fluorescent protein expression originate from a Mafb-expressing population.
MafB deletion in maternal beta-cells also produced GDM, with inadequate beta-cell expansion accompanied by failure to induce PRLR (显示 PRLR 抗体)-dependent target genes regulating beta-cell proliferation. These results unveil molecular roles for PRLR (显示 PRLR 抗体) signaling in orchestrating the physiologic expansion of maternal beta-cells during pregnancy.
MafB play an important role in promoting hindbrain choroid plexus development during embryogenesis
Meanwhile, the observed reduction in the phagocytic activity of the MafB-shRNA-expressing cells was attenuated by ectopic expression of Fcgr3. Together, the results presented here indicate that MafB influences the phagocytic activity of macrophages by promoting Fcgr3, but not Fcgr2b, expression.
The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells. This gene contains no introns.
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
, v-maf musculoaponeurotic fibrosarcoma oncogene protein B
, v-maf musculoaponeurotic fibrosarcoma oncogene homolog B
, Transcription factor MafB
, bzip transcription factor mafB
, transcription factor MafB
, Kreisler maf-related leucine zipper homolog
, MAFB/Kreisler basic region/leucine zipper transcription factor
, Kreisler maf-related leucine zipper homolog (b-maf)
, transcription factor Maf-1
, v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B
, transcription factor Val
, Kreisler (maf-related) leucine zipper protein
, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
, segmentation protein Kr