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promotes cell adhesion and outgrowth of embryonic hippocampal neurons [RGD, Feb 2006]..
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Human Polyclonal SPON2 Primary Antibody for ELISA, WB - ABIN4334535
Manda, Kohno, Matsuno, Takenoshita, Kuwano, Yokota: Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. in Genomics 1999
Spondin-2 overexpression contributes to tumor aggressiveness and prognosis in gastric cancer.
SPON2 is a transcriptional target of the metastasis gene MACC1 (显示 MACC1 抗体). SPON2 induces cell motility in vitro and CRC (显示 CALR 抗体) metastasis in mice. In patients, SPON2 serves as prognostic indicator for CRC (显示 CALR 抗体) metastasis and survival, and might represent a promising target for therapeutic approaches.
Data suggest that spondin-2 could be an independent diagnostic and prognostic biomarker of colon cancer.
Mindin protects against vascular hyperplasia by suppression of abnormal VSMC proliferation, migration and phenotypic switching in an AKT (显示 AKT1 抗体)-dependent manner.
Using tissue microarray by immunohistostaining, we found SPON2 to be over-expressed in prostate cancer (PCa (显示 FLVCR1 抗体)). SPON2 staining was more intense in Gleason score sum 7-8 and in PCa (显示 FLVCR1 抗体) patients with metastasis.
mindin serves as a novel mediator that protects against cardiac hypertrophy and the transition to heart failure by blocking AKT (显示 AKT1 抗体)/GSK3beta and TGF-beta1 (显示 TGFB1 抗体)-Smad (显示 SMAD1 抗体) signalling.
High Mindin is associated with diabetic nephropathy in type 2 diabetes.
Spondin 2, which is regulated by T(3), has an important role in cell invasion, cell migration, and hepatoma tumor progression.
The structure of the F-spondin (显示 SPON1 抗体) domain of mindin was determined at 1.8-A resolution.
Mindin is a novel modulator of hepatic I/R injury through regulating inflammatory responses, as well as hepatocyte apoptosis and proliferation via inactivation of the Akt (显示 AKT1 抗体) signaling pathway.
Spondin 2 regulates hepatic lipid metabolism and alleviates hepatic steatosis, obesity, inflammation, and insulin (显示 INS 抗体) resistance via its interaction with PPARalpha (显示 PPARA 抗体).
The data of this study demonstrated that mindin is a critical mediator of ischemic brain injury in an experimental stroke model.
Data show that mindin, as an intrinsic cardioprotective factor, prevents maladaptive remodelling and the transition to heart failure by blocking AKT/GSK3beta signalling.
Mindin expression is upregulated during intestinal inflammation and may induce NF-kappaBp65 promoter activation in a TLR-9 (显示 TLR9 抗体) mediated manner.
Mindin is a pattern-recognition molecule for microbial pathogens.
Mindin-integrin interactions play a key role in regulating Rho GTPase (显示 RACGAP1 抗体) expression in DCs and DC priming of T lymphocytes.
mindin plays an essential role in the host innate immune response to influenza virus infection and suggest that mindin may be used as an immune-enhancing agent in influenza infection.
mindin participates in integrin-dependent trafficking of eosinophils and can contribute to the severity of allergic airways disease.
promotes cell adhesion and outgrowth of embryonic hippocampal neurons
, differentially expressed in cancerous and non-cancerous lung cells 1