anti-Spindle Assembly 6 Homolog (C. Elegans) (SASS6) 抗体

SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007). 再加上,我们可以发Spindle Assembly 6 Homolog (C. Elegans) 蛋白 (3)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SASS6 310807  
SASS6 163786 Q6UVJ0
SASS6 72776 Q80UK7
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Showing 10 out of 45 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB WB Suggested Anti-SASS6 Antibody Titration: 1.0 ug/ml Positive Control: MCF7 Whole Cell 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 WB SASS6 Antibody (Center)  western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the SASS6 antibody detected the SASS6 protein (arrow). 400 μL Log in to see 10至11个工作日
$324.50
详细
非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 IF (p), IHC (p), WB Paraformaldehyde-fixed, paraffin embedded rat thyroid, Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min, Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes, Blocking buffer (normal goat serum) at 37°C for 30min, Antibody incubation with SASS6 Polyclonal Antibody, Unconjugated  at 1:400 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB staining. 100 μL Log in to see 3至7个工作日
$306.90
详细
小鼠 非结合性 WB Western Blot analysis of SASS6 expression in transfected 293T cell line by SASS6 MaxPab polyclonal antibody.<br><br>Lane 1: SASS6 transfected lysate(53.9 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μg Log in to see 11至12个工作日
$440.00
详细
非结合性 ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: SASS6 Antibody [NBP2-20264] - Immunofluorescence analysis of methanol-fixed HeLa, using antibody at 1:200 dilution. Immunohistochemistry-Paraffin: SASS6 Antibody [NBP2-20264] - Immunohistochemical analysis of paraffin-embedded H441 xenograft, using antibody at 1:100 dilution. 0.1 mL Log in to see 8至11个工作日
$514.63
详细
非结合性 IP Immunoprecipitation: SASS6 Antibody [ABIN4086212] - Detection of Human SAS-6 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibody: Affinity purified rabbit anti-SAS-6 antibody ABIN4086212 used for IP at 3 mcg/mg lysate. SAS-6 was also immunoprecipitated by rabbit anti-SAS-6 antibody ABIN4086213, which recognizes a downstream epitope 100 μL Log in to see 7至9个工作日
$556.31
详细
非结合性 IP, WB Western Blot: SASS6 Antibody [ABIN4086223] - Detection of Human SAS-6 on HeLa whole cell lysate using ABIN4086223. SAS-6 was also IPed by rabbit anti-SAS-6 antibody ABIN4086222. 100 μL Log in to see 7至9个工作日
$556.31
详细
FITC IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细
Cy3 IF (p)   100 μL Log in to see 14至21个工作日
$405.90
详细

通过反应活性、应用领域、克隆类型和共轭标记 SASS6 抗体

特性 应用范围 宿主 克隆类型 标记
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引用最多的anti-Spindle Assembly 6 Homolog (C. Elegans) 抗体

  1. Human Polyclonal SASS6 Primary Antibody for WB - ABIN531143 : Inanç, Pütz, Lalor, Dockery, Kuriyama, Gergely, Morrison: Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells. in Molecular biology of the cell 2013 (PubMed)
    Show all 2 Pubmed References

更多抗Spindle Assembly 6 Homolog (C. Elegans)的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Spindle Assembly 6 Homolog (C. Elegans) (SASS6) interaction partners

  1. These results indicate that centriole biogenesis does not strictly depend on SAS-6 self-assembly, and may require preexisting centrioles to ensure structural accuracy, fundamentally deviating from the current paradigm.

  2. Thus, efficient centriole duplication in flies requires the homo-oligomerisation of both Sas-6 and Ana2.

  3. DSas-6 and Ana2 normally cooperate to drive the formation of the centriole inner cartwheel and they promote both centriole duplication and centriole cohesion in a Sak/Plk4 (显示 PLK4 抗体)-dependent manner.

Human Spindle Assembly 6 Homolog (C. Elegans) (SASS6) interaction partners

  1. Studies indicate that depletion of any one of the protein kinase (显示 CDK7 抗体) polo-like kinase 4 (PLK4 (显示 PLK4 抗体)) and the two proteins STIL (显示 STIL 抗体) and SAS-6 blocks centriole duplication, and, conversely, overexpression causes centriole amplification.

  2. expression of wild-type centriolar assembly protein SAS-6 in a SAS-6-depleted background resulted in centriole sizes that are similar to wild type.

  3. Our present findings revealed that the upregulation of SASS6 expression is involved in the pathogenesis of CRC (显示 CALR 抗体) and is associated with a poor prognosis among patients with colon cancer.

  4. SAS6 possesses an intrinsic microtubule assembly promoting activity and its outer exposed C-terminal tail may play critical roles in microtubule assembly and stabilizing microtubule attachment with the centriolar cartwheel.

  5. A homozygous c.185T>C missense mutation in the HsSAS-6 gene is associated with the cause of autosomal recessive primary microcephaly.

  6. HsSAS-6 homodimers are targeted to centrosomes where the local environment and high concentration of HsSAS-6 promote oligomerization, thus initiating procentriole formation.

  7. Authors propose that CEP135 (显示 CEP135 抗体) directly connects the central hub protein, hSAS (显示 L1CAM 抗体)-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP (显示 CENPJ 抗体)-mediated centriole elongation.

  8. STIL (显示 STIL 抗体) cooperates with SAS-6 and PLK4 (显示 PLK4 抗体) in the control of centriole number and represents a key centriole duplication factor in human cells.

  9. hSAS6 depletion hindered STIL (显示 STIL 抗体) targeting to the procentriole, implying that STIL (显示 STIL 抗体) and hSAS6 are mutually dependent for their centriolar localization.

  10. The activity of SCF (显示 KITLG 抗体)-FBXW5 (显示 FBXW5 抗体) is negatively regulated by Polo-like kinase 4 (PLK4 (显示 PLK4 抗体)), which phosphorylates FBXW5 (显示 FBXW5 抗体) at Ser (显示 SIGLEC1 抗体) 151 to suppress its ability to ubiquitylate HsSAS-6.

Zebrafish Spindle Assembly 6 Homolog (C. Elegans) (SASS6) interaction partners

  1. cea encodes the centriolar coiled-coil protein Sas-6, and that zebrafish Cea/Sas-6 protein localizes to centrosomes.[Cea]

  2. study determined the x-ray structure of the amino-terminal domain of SAS-6 and showed that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers

Spindle Assembly 6 Homolog (C. Elegans) (SASS6) 抗原简介

蛋白简介

SAS6 is necessary for centrosome duplication and functions during procentriole formation\; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007)

Gene names and symbols associated with SASS6

  • SAS-6 centriolar assembly protein (Sass6) 抗体
  • SAS-6 centriolar assembly protein (SASS6) 抗体
  • Spindle assembly abnormal 6 (Sas-6) 抗体
  • spindle assembly 6 homolog L homeolog (sass6.L) 抗体
  • SAS-6 centriolar assembly protein (sass6) 抗体
  • 2810453L12Rik 抗体
  • CG15524 抗体
  • Dmel\\CG15524 抗体
  • dsas-6 抗体
  • Dsas6 抗体
  • RGD1306255 抗体
  • Sas-6 抗体
  • sas6 抗体
  • wu:fb98c12 抗体
  • zgc:55668 抗体

Protein level used designations for SASS6

spindle assembly abnormal protein 6 homolog , CG15524-PA , sas-6-PA , hsSAS-6 , cea , cellular atoll , sas-6

GENE ID SPECIES
310807 Rattus norvegicus
490142 Canis lupus familiaris
504467 Bos taurus
43555 Drosophila melanogaster
431859 Xenopus laevis
163786 Homo sapiens
72776 Mus musculus
424471 Gallus gallus
406747 Danio rerio
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