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SAS6 is necessary for centrosome duplication and functions during procentriole formation; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007).
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Human Polyclonal SASS6 Primary Antibody for WB - ABIN531143
Inanç, Pütz, Lalor, Dockery, Kuriyama, Gergely, Morrison: Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells. in Molecular biology of the cell 2013
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These results indicate that centriole biogenesis does not strictly depend on SAS-6 self-assembly, and may require preexisting centrioles to ensure structural accuracy, fundamentally deviating from the current paradigm.
Thus, efficient centriole duplication in flies requires the homo-oligomerisation of both Sas-6 and Ana2.
DSas-6 and Ana2 normally cooperate to drive the formation of the centriole inner cartwheel and they promote both centriole duplication and centriole cohesion in a Sak/Plk4 (显示 PLK4 抗体)-dependent manner.
Studies indicate that depletion of any one of the protein kinase (显示 CDK7 抗体) polo-like kinase 4 (PLK4 (显示 PLK4 抗体)) and the two proteins STIL (显示 STIL 抗体) and SAS-6 blocks centriole duplication, and, conversely, overexpression causes centriole amplification.
expression of wild-type centriolar assembly protein SAS-6 in a SAS-6-depleted background resulted in centriole sizes that are similar to wild type.
Our present findings revealed that the upregulation of SASS6 expression is involved in the pathogenesis of CRC (显示 CALR 抗体) and is associated with a poor prognosis among patients with colon cancer.
SAS6 possesses an intrinsic microtubule assembly promoting activity and its outer exposed C-terminal tail may play critical roles in microtubule assembly and stabilizing microtubule attachment with the centriolar cartwheel.
A homozygous c.185T>C missense mutation in the HsSAS-6 gene is associated with the cause of autosomal recessive primary microcephaly.
HsSAS-6 homodimers are targeted to centrosomes where the local environment and high concentration of HsSAS-6 promote oligomerization, thus initiating procentriole formation.
Authors propose that CEP135 (显示 CEP135 抗体) directly connects the central hub protein, hSAS (显示 L1CAM 抗体)-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP (显示 CENPJ 抗体)-mediated centriole elongation.
STIL (显示 STIL 抗体) cooperates with SAS-6 and PLK4 (显示 PLK4 抗体) in the control of centriole number and represents a key centriole duplication factor in human cells.
hSAS6 depletion hindered STIL (显示 STIL 抗体) targeting to the procentriole, implying that STIL (显示 STIL 抗体) and hSAS6 are mutually dependent for their centriolar localization.
The activity of SCF (显示 KITLG 抗体)-FBXW5 (显示 FBXW5 抗体) is negatively regulated by Polo-like kinase 4 (PLK4 (显示 PLK4 抗体)), which phosphorylates FBXW5 (显示 FBXW5 抗体) at Ser (显示 SIGLEC1 抗体) 151 to suppress its ability to ubiquitylate HsSAS-6.
cea encodes the centriolar coiled-coil protein Sas-6, and that zebrafish Cea/Sas-6 protein localizes to centrosomes.[Cea]
study determined the x-ray structure of the amino-terminal domain of SAS-6 and showed that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers
SAS6 is necessary for centrosome duplication and functions during procentriole formation\; SAS6 functions to ensure that each centriole seeds the formation of a single procentriole per cell cycle Strnad et al., (2007)
spindle assembly abnormal protein 6 homolog
, cellular atoll