anti-Sphingomyelin Synthase 2 (SGMS2) 抗体

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. 再加上,我们可以发Sphingomyelin Synthase 2 试剂盒 (6)Sphingomyelin Synthase 2 蛋白 (5)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
SGMS2 166929 Q8NHU3
SGMS2 74442 Q9D4B1
SGMS2 310849 Q4JM44
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Showing 10 out of 66 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 WB <b>WB Suggested Anti-SGMS2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>293T cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 EIA, FACS, IHC (p), WB Flow Cytometric analysis of MCF-7 cells using SGMS2 Antibody (C-term) Cat.-No AP53890PU-N (Right histogram) compared to a negative control cell (Left histogram). FITC-conjugated Goat-anti-Rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human brain tissue stained with SGMS2 Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SGMS2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
非结合性 WB Western Blot: Sphingomyelin Synthase 2 Antibody [NBP1-60005] - Titration: 0.2-1 ug/ml, Positive Control: 293T cell lysate. 100 μL Log in to see 8至11个工作日
$485.88
详细
非结合性 EIA, WB Western blot analysis of SGMS2 (arrow) using SGMS2 Antibody (C-term) Cat.-No AP53889PU-N. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SGMS2 gene. 0.4 mL Log in to see 6至8个工作日
$390.50
详细
Bat 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
非结合性 FACS, IHC (p), WB SGMS2 Antibody (C-term) (ABIN653758) western blot analysis in MCF-7,CEM,Hela cell line lysates (35 µg/lane).This demonstrates the SGMS2 antibody detected the SGMS2 protein (arrow). SGMS2 Antibody (C-term) (ABIN653758) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10至11个工作日
$335.50
详细
非结合性 WB Western blot analysis of SGMS2 Antibody (C-term) (ABIN653696) in HepG2 cell line lysates (35 µg/lane). SGMS2 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of SGMS2 Antibody (C-term) (ABIN653696) in mouse spleen tissue lysates (35 µg/lane). SGMS2 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10至11个工作日
$335.50
详细
小鼠 非结合性 RNAi, ELISA, WB Western blot analysis of MGC26963 over-expressed 293 cell line, cotransfected with MGC26963 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with MGC26963 monoclonal antibody (M08), clone 7D10. GAPDH ( 36.1 kDa ) used as specificity and loading control. Western Blot analysis of MGC26963 expression in transfected 293T cell line by MGC26963 monoclonal antibody (M08), clone 7D10.<br><br>Lane 1: MGC26963 transfected lysate(42.3 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μg Log in to see 11至12个工作日
$440.00
详细
非结合性 WB Western Blot: Sphingomyelin Synthase 2 Antibody [NBP1-60004] - Sphingomyelin Synthase 2 expression in mouse lung lysate using anti-Sphingomyelin Synthase 2 antibody. Image from verified customer review. Western Blot: Sphingomyelin Synthase 2 Antibody [NBP1-60004] - Titration: 0.2-1 ug/ml, Positive Control: Human heart. 100 μL Log in to see 8至11个工作日
$485.88
详细
非结合性 FACS, IHC, IHC (p), WB Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE) 200 μL Log in to see 7至9个工作日
$484.00
详细

通过反应活性、应用领域、克隆类型和共轭标记 SGMS2 抗体

特性 应用范围 宿主 克隆类型 标记
Human , ,
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Mouse (Murine)


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Rat (Rattus)


引用最多的anti-Sphingomyelin Synthase 2 抗体

  1. Human Polyclonal Sphingomyelin Synthase 2 Primary Antibody for WB - ABIN4892660 : Ding, Li, Hailemariam, Mukherjee, Maxfield, Wu, Jiang: SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis. in Journal of lipid research 2008 (PubMed)

更多抗Sphingomyelin Synthase 2的相互作用对抗体

Human Sphingomyelin Synthase 2 (SGMS2) interaction partners

  1. SMS (显示 SMS 抗体) regulates the expression and function of drug transporters P-gp (显示 ABCB4 抗体) and MRP2 (显示 ABCC2 抗体).

  2. PPARdelta (显示 PPARD 抗体) activation may be a potential risk of atherosclerosis through enhancing activity of SMS2

  3. F-actin polymerization in the region of HIV-1 membrane fusion was more prominent in Sms2-expressing cells than Sms (显示 SMS 抗体)-deficient cells.

  4. SMS1 (显示 SGMS1 抗体) and SMS2 are capable of regulating TGN (显示 TG 抗体)-mediated protein trafficking and secretion

  5. Data indicate that the increased sphingomyelin mass was due to a rapid and highly specific activation of sphingomyelin synthases SMS1 (显示 SGMS1 抗体) and SMS2.

  6. direct morphological evidence for the pro-atherogenic capabilities of sphingomyelin synthase 2

  7. Data show that SMS2 acting as a bifunctional enzyme with both SM and CPE synthase activity.

  8. Data show that sphingomyelin synthases SMS1 (显示 SGMS1 抗体) and SMS2 are co-expressed in a variety of cell types and function as the key Golgi- and plasma membrane-associated SM synthases in human cervical carcinoma HeLa cells, respectively.

  9. Results indicate that both synthase (SMS)1 (显示 SGMS1 抗体) and 2 contribute to sphingomyelin (SM) de novo synthesis and control SM levels in the cells and on the cell membrane including plasma membrane.

  10. SMS2 is a key factor in control of sphingomyelin and diacylglycerol metabolism within the cell, and thus it influences apoptosis.

Mouse (Murine) Sphingomyelin Synthase 2 (SGMS2) interaction partners

  1. This study showed that MWM learning was deteriorated and associated with depression-like tendency in SMS2 KO mice.

  2. These results demonstrate that SMS2 deficiency inhibits DSS (显示 PMP22 抗体)-induced colitis and subsequent colitis-associated colon cancer via inhibition of colon epithelial cell-mediated inflammation; therefore, inhibition of SMS2 may be a potential therapeutic target for human colitis and colorectal cancer.

  3. It was suggested that very long chain SM but not long chain SM were decreased in SMS2-deficient mice liver and plasma. And the exogenously added very long chain SM (d18:1/24:0) could activate macrophages directly, suggesting a novel role of plasma very long chain SM in modulating macrophage activation and resulting inflammation.

  4. These findings suggested that the degree of lung injury was reduced during the acute inflammatory reaction when NFkappaB was inhibited, and that the expression of sphingomyelin synthase 2 may affect the induction of the NFkappaB pathway by lipopolysaccharide through CD14 (显示 CD14 抗体).

  5. Study provides a mouse model for fetal alcohol spectrum disorder. Due to the accumulation of ceramide in vivo, SMS2 knockout mice allows to investigate how ceramide regulates alcohol-induced neural apoptosis.

  6. study provided evidence that genetic inhibition of SMS2 elevated glucose clearance through activation of glucose uptake into insulin (显示 INS 抗体)-targeted tissues such as skeletal muscle by a mechanism independent of hepatic SMS2

  7. Thus, imaging mass spectrometry can provide visual assessment of the contribution of SMS2 on acyl-chain- and region-specific sphingomyelin metabolism in the kidneys

  8. study reveals that all mouse SMS family members (SMSr, SMS1, and SMS2) have CPE synthase activity

  9. Increasing ceramide levels in the liver can be achieved by SMS2 inhibition to prevent liver steatosis via PPARgamma (显示 PPARG 抗体) suppression.

  10. Data show that LCAT (显示 LCAT 抗体) activity was significantly higher in long chain base biosynthesis protein 2 (Sptlc2 (显示 SPTLC2 抗体))+/- and sphingomyelin synthase 2 (Sms2)-/- mice, but markedly lower in ApoE (显示 APOE 抗体)-/- and Ldlr (显示 LDLR 抗体)-/- mice.

Sphingomyelin Synthase 2 (SGMS2) 抗原简介

蛋白简介

Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.

Gene names and symbols associated with SGMS2

  • sphingomyelin synthase 2 (sgms2) 抗体
  • sphingomyelin synthase 2 (SGMS2) 抗体
  • sphingomyelin synthase 2 (Sgms2) 抗体
  • 4933405A16Rik 抗体
  • 5133401H06Rik 抗体
  • AI854299 抗体
  • RGD1305778 抗体
  • SMS2 抗体
  • spermatin 抗体

Protein level used designations for SGMS2

sphingomyelin synthase 2 , phosphatidylcholine:ceramide cholinephosphotransferase 2 , phosphatidylcholine:ceramide cholinephosphotransferase 2-like , SM synthase

GENE ID SPECIES
496853 Xenopus (Silurana) tropicalis
695947 Macaca mulatta
735414 Pan troglodytes
100072971 Equus caballus
100079264 Ornithorhynchus anatinus
100400486 Callithrix jacchus
100446194 Pongo abelii
100466473 Ailuropoda melanoleuca
100593842 Nomascus leucogenys
166929 Homo sapiens
556193 Danio rerio
422529 Gallus gallus
478505 Canis lupus familiaris
100518796 Sus scrofa
520954 Bos taurus
74442 Mus musculus
310849 Rattus norvegicus
100715504 Cavia porcellus
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