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Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. 再加上，我们可以发Sphingomyelin Synthase 2 试剂盒 (6) 和 Sphingomyelin Synthase 2 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal Sphingomyelin Synthase 2 Primary Antibody for WB - ABIN4892660
Ding, Li, Hailemariam, Mukherjee, Maxfield, Wu, Jiang: SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis. in Journal of lipid research 2008
SMS regulates the expression and function of drug transporters P-gp and MRP2.
findings suggest that the C-terminal tails of SMSs are involved in homodimer formation, which is required for efficient transport from the ER.
PPARdelta activation may be a potential risk of atherosclerosis through enhancing activity of SMS2
F-actin polymerization in the region of HIV-1 membrane fusion was more prominent in Sms2-expressing cells than Sms-deficient cells.
SMS1 and SMS2 are capable of regulating TGN-mediated protein trafficking and secretion
Data indicate that the increased sphingomyelin mass was due to a rapid and highly specific activation of sphingomyelin synthases SMS1 and SMS2.
direct morphological evidence for the pro-atherogenic capabilities of sphingomyelin synthase 2
Data show that SMS2 acting as a bifunctional enzyme with both SM and CPE synthase activity.
Data show that sphingomyelin synthases SMS1 and SMS2 are co-expressed in a variety of cell types and function as the key Golgi- and plasma membrane-associated SM synthases in human cervical carcinoma HeLa cells, respectively.
Results indicate that both synthase (SMS)1 and 2 contribute to sphingomyelin (SM) de novo synthesis and control SM levels in the cells and on the cell membrane including plasma membrane.
SMS2 is a key factor in control of sphingomyelin and diacylglycerol metabolism within the cell, and thus it influences apoptosis.
SMS2 regulates subcellular pools of diacylglycerol-binding proteins in the Golgi apparatus.
SMS2 (Sphingomyelin synthase 2) physiologically contributes to de novo Sphingomyelin biosynthesis and plasma membrane Sphingomyelin levels
Both SMS1 and SMS2 contain two histidines and one aspartic acid which are conserved within the lipid phosphate phosphatase superfamily. Site-directed mutagenesis of these amino acids abolished SMS activity without altering cellular distribution.
These results suggested that posttranslational palmitoylation is important for determination of the subcellular localization of SMS2.
Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice.
Sphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.
sphingomyelin synthase 2
, phosphatidylcholine:ceramide cholinephosphotransferase 2
, phosphatidylcholine:ceramide cholinephosphotransferase 2-like
, SM synthase