anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) 抗体

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. 再加上,我们可以发RUNX1T1 蛋白 (6)RUNX1T1 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
RUNX1T1 362489  
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Showing 10 out of 51 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
Cow 非结合性 IHC, WB <b>WB Suggested Anti-RUNX1T1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 WB 100 μL Log in to see 2至3个工作日
$289.00
详细
Cow 非结合性 WB WB Suggested Anti-RUNX1T1 Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate There is BioGPS gene expression data showing that RUNX1T1 is expressed in HepG2 Host:  Rabbit  Target Name:  WT1  Sample Type:  721_B  Antibody Dilution:  1.0ug/ml  RUNX1T1 is supported by BioGPS gene expression data to be expressed in 721_B 100 μL Log in to see 2至3个工作日
$229.00
详细
非结合性 ChIP, ELISA 50 μL Log in to see 2至3个工作日
$245.00
详细
Bat 非结合性 WB 100 μg Log in to see 7至9个工作日
$493.17
详细
小鼠 非结合性 ELISA, IF, WB Western Blot analysis of RUNX1T1 expression in transfected 293T cell line by RUNX1T1 monoclonal antibody (M01), clone 5A12.Lane 1: RUNX1T1 transfected lysate(67.566 KDa).Lane 2: Non-transfected lysate. Dilution: 1:500~1000 100 μg Log in to see 8至11个工作日
$461.00
详细
非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
Bat 非结合性 WB 50 μg Log in to see 7至9个工作日
$551.83
详细
小鼠 非结合性 IF, WB Anti-RUNX1T1 mouse monoclonal antibody (ABIN2455775) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RUNX1T1 (RC222426). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RUNX1T1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-RUNX1T1. 0.1 mL Log in to see Available
$482.90
详细
非结合性 IHC   0.1 mg Log in to see 4至6个工作日
$302.50
详细

引用最多的anti-RUNX1T1 抗体

  1. Human Polyclonal RUNX1T1 Primary Antibody for ELISA, WB - ABIN560189 : Abdelhaleem: RNA helicases: regulators of differentiation. in Clinical biochemistry 2005 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal RUNX1T1 Primary Antibody for IHC - ABIN965546 : Liu, Shen, Huynh, Klisovic, Rush, Ford, Yu, Becknell, Li, Liu, Vukosavljevic, Whitman, Chang, Byrd, Perrotti, Plass, Marcucci: Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. in Cancer research 2005 (PubMed)
    Show all 10 Pubmed References

更多抗RUNX1T1的相互作用对抗体

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. PKM2 (显示 PKM 抗体) as a novel target of RUNX1 (显示 RUNX1 抗体)-ETO and is specifically downregulated in RUNX1 (显示 RUNX1 抗体)-ETO positive AML (显示 RUNX1 抗体) patients, indicating that PKM2 (显示 PKM 抗体) level might have a diagnostic potential in RUNX1 (显示 RUNX1 抗体)-ETO associated AML (显示 RUNX1 抗体).

  2. The specific association of ZBTB7A (显示 ZBTB7A 抗体) mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A (显示 ZBTB7A 抗体) and the RUNX1 (显示 RUNX1 抗体)/RUNX1T1 fusion protein has been reported.

  3. Data indicate miR (显示 MLXIP 抗体)-29b-1 as a regulator of the AML1 (显示 RUNX1 抗体)-ETO protein (RUNX1 (显示 RUNX1 抗体)-RUNX1T1), and that miR (显示 MLXIP 抗体)-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  4. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1 (显示 RUNX1 抗体)-ETO/THAP10 (显示 THAP10 抗体)/miR (显示 MLXIP 抗体)-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 (显示 THAP10 抗体) predicts a poor clinical outcome and represents a novel therapeutic target.

  5. RUNX1 (显示 RUNX1 抗体)-RUNX1T1 transcript levels were measured in bone marrow samples collected from 208 patients at scheduled time points after transplantation. Over 90% of the 175 patients who were in continuous complete remission had a >/=3-log reduction in RUNX1 (显示 RUNX1 抗体)-RUNX1T1 transcript levels from the time of diagnosis at each time point after transplantation and a >/=4-log reduction at >/=12 months.

  6. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (显示 TFF1 抗体) are mechanistically connected to CEBPB (显示 CEBPB 抗体) and that cross-regulation between CEBPB (显示 CEBPB 抗体)-RUNX1t1-TFF1 (显示 TFF1 抗体) plays an important role in gastric carcinogenesis.

  7. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  8. Leukaemogenesis by AML1 (显示 RUNX1 抗体)-ETO requires enhanced C/D box snoRNA/RNP (显示 RNPC3 抗体) formation.

  9. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (显示 RUNX1 抗体)-175) of AML1 (显示 RUNX1 抗体)-ETO is consistent with its contribution to the activity of full-length AML1 (显示 RUNX1 抗体)-ETO and is mediated through its direct association with the DNA-binding domain

  10. the AML1 (显示 RUNX1 抗体)-ETO fusion protein increases the expression of SIRT1 (显示 SIRT1 抗体), possibly by binding to the promoter region of SIRT1 (显示 SIRT1 抗体) to activate its transcription in t(8;21) AML (显示 RUNX1 抗体).

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Results suggest that AML1 (显示 RUNX1 抗体)/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (显示 TFF1 抗体) are mechanistically connected to CEBPB (显示 CEBPB 抗体) and that cross-regulation between CEBPB (显示 CEBPB 抗体)-RUNX1t1-TFF1 (显示 TFF1 抗体) plays an important role in gastric carcinogenesis.

  3. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  4. Leukaemogenesis by AML1 (显示 RUNX1 抗体)-ETO requires enhanced C/D box snoRNA/RNP (显示 RNPC3 抗体) formation.

  5. Data show that RUNX1 (显示 RUNX1 抗体)-ETO;c-Kit (显示 KIT 抗体)(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (显示 BCL11A 抗体) (AML (显示 RUNX1 抗体)) in a fraction (51%) of reconstituted mice.

  6. Self-renewal induced by AML1 (显示 RUNX1 抗体)/ETO in primary murine progenitors was inhibited when Aes (显示 AES 抗体) was decreased or absent.

  7. AML1 (显示 RUNX1 抗体)-ETO synergizes with an ICSBP (显示 IRF8 抗体) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  8. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (显示 CEBPB 抗体) and a novel regulator of early adipogenesis

  9. the loss of the molecular events of AML1 (显示 RUNX1 抗体)-ETO C-terminal NCoR (显示 NCOR1 抗体)/SMRT-interacting domain transforms AML1 (显示 RUNX1 抗体)-ETO into a potent leukemogenic protein

  10. p15(Ink4b (显示 CDKN2B 抗体)) loss must be accompanied by additional oncogenic changes for RUNX1 (显示 RUNX1 抗体)-ETO-associated AML (显示 RUNX1 抗体) to develop

RUNX1T1 抗原简介

蛋白简介

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) 抗体
  • RUNX1 translocation partner 1 L homeolog (runx1t1.L) 抗体
  • RUNX1 translocation partner 1 (RUNX1T1) 抗体
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) 抗体
  • RUNX1 translocation partner 1 (Runx1t1) 抗体
  • AML1T1 抗体
  • Cbfa2t1 抗体
  • Cbfa2t1h 抗体
  • CDR 抗体
  • ETO 抗体
  • MTG8 抗体
  • si:ch211-232j17.1 抗体
  • wu:fi14b07 抗体
  • zgc:154044 抗体
  • ZMYND2 抗体

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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