RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
Alias Symbols: CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1
Protein Interaction Partner: EPS8, NECAB2, ABI3, GSE1, MID2, SPRY2, HOMER3, LPXN, ZMYM4, STX11, MEOX2, CCDC36, TRIM42, SPERT, CREB3L1, LZTS2, EFHC2, CPSF7, C19orf57, PRDM14, CBFA2T2, NCOR1, UBQLN4, ATN1, BCL6, ETS1, RUNX1, DNMT1, SPEN, RBPJ, UBE2E2, UBC, TRIM33, HDAC1, NCOR2, SIN3A,
Protein Size: 604