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The protein encoded by POLR1C is a subunit of both RNA polymerase I and RNA polymerase III complexes. 再加上，我们可以发POLR1C 蛋白 (9) 和 和数多这个蛋白质的别的产品。
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Our work therefore has uncovered tissue-specific roles for polr1c and polr1d in rRNA transcription, ribosome biogenesis, and neural crest and craniofacial development during embryogenesis.
Treacher Collins syndrome 3-associated mutation leads to the localization of POLR1C into the lysosome and inhibits chondrogenic differentiation, possibly explaining a portion of the pathological molecular basis underlying Treacher Collins syndrome.
We report a clinical and extensive molecular study, including TCOF1, POLR1D, POLR1C, and EFTUD2 genes, in a series of 146 patients with TCS.
This study is the first to show that distinct mutations in a gene coding for a shared subunit of two RNA polymerases lead to selective modification of the enzymes' availability leading to two different clinical conditions.
Mutations in TCOF1, POLR1C and POLR1D have all been implicated in causing TCS
mutations in both alleles of POLR1C in three individuals with Treacher Collins syndrome.
analyzed the kinetics of assembly and elongation of the RNA polymerase I complex on endogenous ribosomal genes in the nuclei of living cells with the use of in vivo microscopy
The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Defects in this gene have been associated with Treacher Collins syndrome (TCS).
DNA-directed RNA polymerases I and III subunit RPAC1
, polymerase (RNA) I polypeptide C, 30kDa
, RNA polymerase I subunit
, DNA-directed RNA polymerases I and III subunit RPAC1-like
, DNA-directed RNA polymerase I subunit C
, DNA-directed RNA polymerases I and III 40 kDa polypeptide
, RNA polymerase 1-1 (40 kDa subunit)
, RNA polymerases I and III subunit AC1
, RNA polymerase 1-1