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PSMC3IP encodes a protein that functions in meiotic recombination. 再加上，我们可以发PSMC3 Interacting Protein 试剂盒 (6) 和 PSMC3 Interacting Protein 蛋白 (5)和数多这个蛋白质的别的产品。
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Human Polyclonal PSMC3IP Primary Antibody for IHC, IHC (p) - ABIN4348271
Capdevila-Busquets, Badiola, Arroyo, Alcalde, Soler-López, Aloy: Breast cancer genes PSMC3IP and EPSTI1 play a role in apoptosis regulation. in PLoS ONE 2015
Show all 3 Pubmed References
HOP2-MND1 (显示 MND1 抗体) enhances the interaction of RAD51 (显示 RAD51 抗体) with nucleotide cofactors and modifies its DNA-binding specificity.
Results show the role of a coiled-coil structural feature involved in HOP2 self-association.
Authors propose that HOP2 may act as a recombinase (显示 RAG1 抗体) with specific functions in meiosis.
C-terminal basic region of TBPIP/HOP2 is required for efficient DNA binding and is also essential for its homologous pairing stimulation activity
data reveal an interplay among Hop2, Mnd1 (显示 MND1 抗体) and Rad51 (显示 RAD51 抗体) and Dmc1 (显示 DMC1 抗体) in the formation of the first recombination intermediates during meiosis
Hop2/Mnd1 (显示 MND1 抗体) greatly stimulates Dmc1 (显示 DMC1 抗体) to promote synaptic complex formation on long duplex DNAs
The PSMC3IP mutation provides additional evidence that mutations in meiotic homologous recombination and DNA repair genes result in distinct female and male reproductive phenotypes, including delayed puberty and primary amenorrhea caused by Primary ovarian insufficiency (XX gonadal dysgenesis) in females but isolated azoospermia with normal pubertal development in males.
PSMC3IP gene mutations are not common causes of primary ovarian insufficiency in this Swedish cohort.
GT198 mutant luteinized theca cells overexpressing CYP17 (显示 CYP17A1 抗体) are common in ovarian cancer stroma.
a PSMC3IP/HOP2 mutation may cause XX ovarian dysgenesis through abolishing coactivation of estrogen-driven transcription
Data suggest that the human TBPIP/Hop2-Mnd1 (显示 MND1 抗体) complex may ensure proper pairing between homologous chromosomes through its stimulation of strand exchange during meiosis.
findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP.
Identification of GT198 (TBPIP/Hop2) as a nuclear receptor coactivator. GT198 is phosphorylation regulated (显示 PHAX 抗体). GT198 interacts with nuclear receptors.
This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants.
homologous-pairing protein 2 homolog
, Homologous-pairing protein 2 homolog
, PSMC3 interacting protein
, PSMC3-interacting protein
, TBP-1-interacting protein
, proteasome 26S ATPase subunit 3-interacting protein
, tat-binding protein 1-interacting protein
, nuclear receptor coactivator GT198
, proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein