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LAMC2 蛋白

(Laminin, gamma 2 (LAMC2))
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain\; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011].
LAMC2 Protein (AA 1084-1193) (His tag) LAMC2 Protein (AA 1084-1193) (His tag) LAMC2 Protein (AA 1084-1193) (His tag) (ABIN7123715)

LAMC2 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

LAMC2 Protein (AA 1084-1193) (GST tag) LAMC2 Protein (AA 1084-1193) (GST tag) LAMC2 Protein (AA 1084-1193) (GST tag) (ABIN1309132)

LAMC2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

LAMC2 Protein (AA 28-196) (His tag) (ABIN7395860)

LAMC2 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % WB, SDS, Imm, PC

LAMC2 蛋白 by Origin

Find LAMC2 蛋白 for a variety of species such as anti-Human LAMC2, anti-Mouse LAMC2, anti-Rat LAMC2. The species listed below are among those available. Click on a link to go to the corresponding products.

LAMC2 蛋白 by Source

Here you will find LAMC2 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

LAMC2 蛋白 by 蛋白类型

Here you can find LAMC2 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

LAMC2 蛋白 by 应用范围

Find LAMC2 蛋白 validated for a specific application such as WB, SDS, Imm, PC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular LAMC2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123715
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309132
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7395860
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7414768
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7414864
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7415071
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7404002
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN6964244
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3010420
Quantity 100 μg
Datasheet Datasheet

Aliases for LAMC2 蛋白

laminin subunit gamma 2 (LAMC2) 蛋白
laminin, gamma 2 (Lamc2) 蛋白
laminin subunit gamma 2 (Lamc2) 蛋白
AA589349 蛋白
B2T 蛋白
BM600 蛋白
CSF 蛋白
EBR2 蛋白
EBR2A 蛋白
LAMB2T 蛋白
LAMC2 蛋白
LAMNB2 蛋白
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