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Involved in the biogenesis of the 60S ribosomal subunit. 再加上，我们可以发LAS1L 蛋白 (3) 和 和数多这个蛋白质的别的产品。
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LAS1L interacts with PELP1 (显示 PELP1 抗体), TEX10, and WDR18 (显示 WDR18 抗体), the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 (显示 NOL9 抗体) and SENP3 (显示 ULP1 抗体), to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit.
Analysis of high-molecular-weight RNAs confirmed that Las1L is required for ITS2 processing,which separates the 5.8S and 25S/28S rRNAs, as 32S was found to accumulate and 12S to diminish upon Las1L depletion.
Data demonstrate that Las1L is essential for cell proliferation and biogenesis of the 60S ribosomal subunit.
Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA (By similarity).
, protein LAS1 homolog
, ribosomal biogenesis protein LAS1L