Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 2 蛋白 (KIR3DL2)

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. 再加上,我们可以发KIR3DL2 抗体 (35)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
KIR3DL2 3812 P43630
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KIR3DL2 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
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Human Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 2 (KIR3DL2) interaction partners

  1. We show that KIR3DL2 expression is the most sensitive diagnostic criterion of Sezary syndrome when compared with all other available biological criteria. KIR3DL2 therefore represents a valuable tool for routine use as a clinical parameter at diagnosis, for prognosis and during patient follow-up

  2. results identified significant KIR3DL2 expression in all cutaneous T-cell lymphomas subtypes

  3. Overexpression of a single MHCI molecule, HLA-F, protects human MNs from ALS astrocyte-mediated toxicity, whereas knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2, on human astrocytes results in enhanced motor neurons death

  4. KIR-3DL2 binding to HLA-B27 licenses Th17 cell differentiation in spondyloarthritis.

  5. In early axial spondyloarthritis and ankylosing spondylitis Dutch patients, no copy number changes were found for KIR3DL2.

  6. we show that the allele KIR3DL2*001 and the single nucleotide polymorphism 1190T (rs3745902) are associated with differential susceptibility to pemphigus

  7. CD158k expression was identified on cutaneous CD4+ T cells in healthy individuals and also mycosis fungoides patients.

  8. These findings provide novel insights about the molecular basis of KIR3DL2 binding to B27

  9. these data provide evidence for a possible role of KIR3DL2 in the maintenance of a high circulating malignant-cell burden by preventing activation-induced cell death.

  10. Our results indicate that KIR3DL2 can directly promote Sezary syndrome malignant cell death through the use of CpG ODN.

  11. our results show that a multistep gating of CD158k+ cells is reliable to assess tumor burden in case of Sezary syndrome.

  12. our results offer preclinical proof of concept for the clinical development of IPH4102, a humanized monoclonal antibody that targets the immune receptor KIR3DL2,to treat patients with nced cutaneous T-cell lymphoma

  13. KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis.

  14. PLS3, Twist, KIR3DL2 and NKp46 gene expression can model efficient molecular Sezary syndrome diagnosis.

  15. most frequently expressed KIR receptor in transformed mycosis fungoides

  16. The frequencies of alleles of killer cell immunoglobulin-like receptor genes, KIR3DL3 and KIR3DL2, and the carrier frequency of KIR2DL4 alleles have been determined from a population of African Americans by DNA sequencing of the coding regions.

  17. results suggest that carriers of A allele in exon 3 of killer cell immunoglobulin-like receptor 3DL2(KIR3DL2) have a decreased susceptibility to preeclampsia

  18. Enhanced proliferation, survival, and interleukin (IL)-17 production of KIR3DL2+ CD4 T cells stimulated with antigen-presenting cells expressing HLA-B27 homodimers suggest new therapeutic strategies in ankylosing spondylitis.

  19. Data show direct binding of KIR3DL2 to ODNs and we show that the D0 domain is involved primarily in this interaction.

  20. The A52G polymorphism in exon 3 and the frequencies of C32T in exon 9 of KIR3DL2 gene polymorphism are associated with the pathogenesis of pre-eclampsia.

蛋白简介KIR3DL2

蛋白简介

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with KIR3DL2

  • killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 (KIR3DL2)
  • CD158K 蛋白
  • NKAT-4 蛋白
  • NKAT4 蛋白
  • NKAT4B 蛋白
  • p140 蛋白

Protein level used designations for KIR3DL2

CD158 antigen-like family member K , KIR antigen 3DL2 , MHC class I NK cell receptor , killer Ig receptor , killer cell immunoglobulin-like receptor 3DL2 , killer cell immunoglobulin-like receptor KIR3DL2 , natural killer cell inhibitory receptor , natural killer-associated transcript 4 , p70 NK receptor CL-5 , p70 killer cell inhibitory receptor , p70 natural killer cell receptor clone CL-5

GENE ID SPECIES
3812 Homo sapiens
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