Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 2 蛋白 (KIR3DL2)

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. 再加上,我们可以发KIR3DL2 抗体 (33)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
KIR3DL2 3812 P43630
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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KIR3DL2 蛋白 by Origin and Source

Origin 在表达 标记
Human , ,
, , ,

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Human Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 2 (KIR3DL2) interaction partners

  1. We show that KIR3DL2 expression is the most sensitive diagnostic criterion of Sezary syndrome when compared with all other available biological criteria. KIR3DL2 therefore represents a valuable tool for routine use as a clinical parameter at diagnosis, for prognosis and during patient follow-up

  2. results identified significant KIR3DL2 expression in all cutaneous T-cell lymphomas subtypes

  3. Overexpression of a single MHCI molecule, HLA-F (显示 HLAF 蛋白), protects human MNs (显示 FLNA 蛋白) from ALS (显示 IGFALS 蛋白) astrocyte-mediated toxicity, whereas knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2, on human astrocytes results in enhanced motor neurons death

  4. KIR-3DL2 binding to HLA-B27 licenses Th17 cell differentiation in spondyloarthritis.

  5. In early axial spondyloarthritis and ankylosing spondylitis Dutch patients, no copy number changes were found for KIR3DL2.

  6. we show that the allele KIR3DL2*001 and the single nucleotide polymorphism 1190T (rs3745902) are associated with differential susceptibility to pemphigus

  7. CD158k expression was identified on cutaneous CD4 (显示 CD4 蛋白)+ T cells in healthy individuals and also mycosis fungoides patients.

  8. These findings provide novel insights about the molecular basis of KIR3DL2 binding to B27

  9. these data provide evidence for a possible role of KIR3DL2 in the maintenance of a high circulating malignant-cell burden by preventing activation-induced cell death.

  10. Our results indicate that KIR3DL2 can directly promote Sezary syndrome malignant cell death through the use of CpG ODN.

蛋白简介KIR3DL2

蛋白简介

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with KIR3DL2

  • killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 (KIR3DL2)
  • CD158K 蛋白
  • NKAT-4 蛋白
  • NKAT4 蛋白
  • NKAT4B 蛋白
  • p140 蛋白

Protein level used designations for KIR3DL2

CD158 antigen-like family member K , KIR antigen 3DL2 , MHC class I NK cell receptor , killer Ig receptor , killer cell immunoglobulin-like receptor 3DL2 , killer cell immunoglobulin-like receptor KIR3DL2 , natural killer cell inhibitory receptor , natural killer-associated transcript 4 , p70 NK receptor CL-5 , p70 killer cell inhibitory receptor , p70 natural killer cell receptor clone CL-5

GENE ID SPECIES
3812 Homo sapiens
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