KIR3DL2 产品
(Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 2 (KIR3DL2))
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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011].
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Featured KIR3DL2 Categories
KIR3DL2 抗体
High quality antibodies with extensive validation data.
KIR3DL2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KIR3DL2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7189471
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, ICC
Validations
- (2)
Cat. No.
ABIN2856893
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
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ELISA, IF
Validations
- (1)
Cat. No.
ABIN7157528
Quantity
100 μg
Datasheet
Datasheet
Recommended KIR3DL2 蛋白
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Reactivity
Source
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Source
HEK-293 Cells
Validations
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Cat. No.
ABIN7275102
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rhesus Monkey
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275101
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3082703
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KIR3DL2 Products
: "Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 3, pp. 1146-1158, (2018) (PubMed).: "α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 199, Issue 6, pp. 2030-2042, (2017) (PubMed).
: "The Incubation Period of Primary Epstein-Barr Virus Infection: Viral Dynamics and Immunologic Events." in: PLoS pathogens, Vol. 11, Issue 12, pp. e1005286, (2015) (PubMed).
: "Contenders in FasL/TNF death signaling." in: Cell, Vol. 81, Issue 4, pp. 479-82, (1995) (PubMed).
Synonyms and alternative names related to KIR3DL2
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2 (KIR3DL2), CD158K, NKAT-4, NKAT4, NKAT4B, p140Protein level used designations for KIR3DL2
- CD158 antigen-like family member K
- KIR antigen 3DL2
- MHC class I NK cell receptor
- killer Ig receptor
- killer cell immunoglobulin-like receptor 3DL2
- killer cell immunoglobulin-like receptor KIR3DL2
- natural killer cell inhibitory receptor
- natural killer-associated transcript 4
- p70 NK receptor CL-5
- p70 killer cell inhibitory receptor
- p70 natural killer cell receptor clone CL-5
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