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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. 再加上，我们可以发IL27 抗体 (164) 和 IL27 试剂盒 (58)和数多这个蛋白质的别的产品。
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Human IL27 Protein expressed in Wheat germ - ABIN1307800
Di Meo, Airoldi, Sorrentino, Zorzoli, Esposito, Di Carlo: Interleukin-30 expression in prostate cancer and its draining lymph nodes correlates with advanced grade and stage. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
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IL-27 enhances the potential of reactive oxygen species generation from monocyte-derived macrophages and dendritic cells by induction of p47(phox).
IL-27 has a unique ability to directly act on hematopoietic stem cells and promote their expansion and differentiation into myeloid progenitors in hematologic neoplasms and malaria. (Review)
IL-27 rs153109 and rs17855750 Polymorphisms are associated with Risk and Response to Therapy in Acute Lymphoblastic Leukemia.
IL-27 was down-regulated in the malignant Middle Cerebral Artery Infarction.
IL-27 may be involved in the development of coronary artery lesions in acute Kawasaki disease.
Hepatitis B virus infection can lead to overexpression of interleukin-27 gene in liver transplant patients.
this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer
IL-27 signaling (IL-27 and its receptor) may be involved in the pathogenesis of HIV infection and immune reconstitution in HIV/AIDS patients who underwent HAART. IL-27 may exert effects through regulating Th1 (显示 TH1L 蛋白) / Th2 ratio.
This study provides additional evidence that IL-27 may contribute to autoimmune processes in MS patients.
this study shows that IL-27 regulates the adherence, proliferation, and migration of placenta-derived mesenchymal stromal cells and enhances their regulatory effects on Th1 (显示 TH1L 蛋白) and Th2 subset generations
Mechanistic studies have identified that hyperlipidemia induces IL-27 production in a TLR4 (显示 TLR4 蛋白)-dependent manner, likely via downregulating LXR (显示 NR1H3 蛋白) expression in dendritic cells. In this case, mice lacking IL-27 do not develop enhanced antibody responses.
IFN-gamma (显示 IFNG 蛋白) induces IL-30 production which suppresses IFN-gamma (显示 IFNG 蛋白) mediated liver inflammation.
IL-27 signaling in Foxp3 (显示 FOXP3 蛋白)(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system
this study has revealed an important role of thymic dendritic cells-derived IL-27 in the regulation of the phenotypic maturation of CD4 (显示 CD4 蛋白)(+) single positive thymocytes.
TTP (显示 ZFP36 蛋白), encoded by Zfp36 (显示 ZFP36 蛋白), degrades p28 (显示 GSTO1 蛋白) to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.
these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1 (显示 TXNRD1 蛋白)-like cells in celiac disease
endogenous levels of IL-27 affected the oncogenic properties of mutant p53 (显示 TP53 蛋白) in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.
Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin (显示 LTF 蛋白).
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interluekin 27
, interleukin 27
, interleukin 27 p28 subunit