Interleukin 27 蛋白 (IL27)

The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. 再加上,我们可以发IL27 抗体 (164)IL27 试剂盒 (54)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
IL27 246778 Q8NEV9
IL27 365368  
IL27 246779 Q8K3I6
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人细胞 小鼠 His tag 10 μg Log in to see 14至16个工作日
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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CHO Cells His tag 10 μg Log in to see 14至16个工作日
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大肠杆菌(E. Coli) 小鼠 非结合性 100 μg Log in to see 1至2个工作日
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
$5,370.21
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大肠杆菌(E. Coli) 小鼠 His tag 100 μg Log in to see 15至18个工作日
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大肠杆菌(E. Coli) 大鼠 His tag 100 μg Log in to see 15至18个工作日
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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大肠杆菌(E. Coli) 小鼠 非结合性   1 mg Log in to see 2至3个工作日
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大肠杆菌(E. Coli) 小鼠 非结合性 Lane 1: non-reducing conditions Lane 2: reducing conditions 10 μg Log in to see 11至12个工作日
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IL27 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , ,
,
Rat (Rattus)

Mouse (Murine) , ,

引用最多的IL27 蛋白

  1. Human IL27 Protein expressed in Wheat germ - ABIN1307800 : Di Meo, Airoldi, Sorrentino, Zorzoli, Esposito, Di Carlo: Interleukin-30 expression in prostate cancer and its draining lymph nodes correlates with advanced grade and stage. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014 (PubMed)
    Show all 2 Pubmed References

更多Interleukin 27 (IL27)互动伙伴

Human Interleukin 27 (IL27) interaction partners

  1. Over-expression of IL-17 and IL-27 are involved in the pathogenesis of liver damage in children with human cytomegalovrius infection.

  2. Interleukin-27 differentially regulates the expression of seven novel microRNAs.

  3. Patients with tuberculous pleural effusion have an about 26-fold higher chance of being IL-27 test-positive compared to patients with malignant pleural effusion. [meta-analysis]

  4. there was a significant increase in the risk of Kawasaki disease with coronary arterial lesions in children with the rs17855750 (T>G), rs40837 (A>G), rs4740 (G>A), rs4905 (A>G), rs153109 (T>C), and rs26528 (A>G) Single-nucleotide Polymorphisms.

  5. our results showed that SNP rs153109 displayed significant associations with dilated cardiomyopathy in Chinese Han population, whereas no differences in genotype or allele frequencies were found between dilated cardiomyopathy patients and controls at SNP rs17855750.

  6. Human Immunodeficiency virus type-1 myeloid derived suppressor cells inhibit cytomegalovirus inflammation through IL-27 and B7-H4.

  7. IL-27 enhances the potential of reactive oxygen species generation from monocyte-derived macrophages and dendritic cells by induction of p47(phox).

  8. IL-27 has a unique ability to directly act on hematopoietic stem cells and promote their expansion and differentiation into myeloid progenitors in hematologic neoplasms and malaria. (Review)

  9. IL-27 rs153109 and rs17855750 Polymorphisms are associated with Risk and Response to Therapy in Acute Lymphoblastic Leukemia.

  10. IL-27 was down-regulated in the malignant Middle Cerebral Artery Infarction.

  11. IL-27 may be involved in the development of coronary artery lesions in acute Kawasaki disease.

  12. Hepatitis B virus infection can lead to overexpression of interleukin-27 gene in liver transplant patients.

  13. this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer

  14. IL-27 signaling (IL-27 and its receptor) may be involved in the pathogenesis of HIV infection and immune reconstitution in HIV/AIDS patients who underwent HAART. IL-27 may exert effects through regulating Th1 / Th2 ratio.

  15. This study provides additional evidence that IL-27 may contribute to autoimmune processes in MS patients.

  16. this study shows that IL-27 regulates the adherence, proliferation, and migration of placenta-derived mesenchymal stromal cells and enhances their regulatory effects on Th1 and Th2 subset generations

  17. This study failed to find an association between common variants in the functional region of IL27 and coronary artery disease in a Chinese Han population

  18. Data point out to a broad set of activities shared by IL-27 and IFN-gamma, which are dependent on the common activation of the STAT1 pathway. These data add further explanation to the anti-tumor activity of IL-27 and also to its dual role in immune regulation

  19. The current meta-analysis suggests that IL-27 -964A/G polymorphism might enhance cancer risk. However, large-scale and well-designed studies are still needed to confirm the result of our meta-analysis

  20. this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth

Mouse (Murine) Interleukin 27 (IL27) interaction partners

  1. data suggested that IL-27/IL-27R expression induced by Toxoplasma gondii infection may regulate mast cell-mediated immune response during acute ocular toxoplasmosis in mouse model

  2. IL-27 has a unique ability to directly act on hematopoietic stem cells and promote their expansion and differentiation into myeloid progenitors in hematologic neoplasms and malaria. (Review)

  3. Mechanistic studies have identified that hyperlipidemia induces IL-27 production in a TLR4-dependent manner, likely via downregulating LXR expression in dendritic cells. In this case, mice lacking IL-27 do not develop enhanced antibody responses.

  4. IFN-gamma induces IL-30 production which suppresses IFN-gamma mediated liver inflammation.

  5. IL-27 signaling in Foxp3(+) Tregs essential for Tregs to control autoimmune inflammation in the central nervous system

  6. this study indicates that IL-27 secreted by cervical carcinoma cells restricts the angiogenesis in a paracrine manner in the pathogenesis of cervical cancer

  7. this study has revealed an important role of thymic dendritic cells-derived IL-27 in the regulation of the phenotypic maturation of CD4(+) single positive thymocytes.

  8. TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

  9. these data infer that endopeptidase mediated gliadin degradation by macrophages and concomitant IL-27 production drive differentiation of splenic gliadin-specific Tr1-like cells in celiac disease

  10. endogenous levels of IL-27 affected the oncogenic properties of mutant p53 in vivo in a Li-Fraumeni mouse model. Lack of IL-27 signaling led to shortened survival times and increased incidence of osteosarcomas.

  11. Interleukin-27 is upregulated centrally and peripherally after intracerebral hemorrhage. Interleukin-27 promotes the tissue-protecting functions of neutrophils via, at least partly, the induction of lactoferrin.

  12. Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS injection compared with control specimens.

  13. these findings highlight critical roles for IFN-gamma and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation

  14. IL-27-induced Sca-1(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes and Blimp1.

  15. found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27

  16. We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.

  17. These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.

  18. results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.

  19. These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta secretion levels triggered by dual LPS-ATP stimulation.

  20. findings show that PGE2 inhibits IL-27 production in macrophages and in splenic conventional dendritic cells; and identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site

Pig (Porcine) Interleukin 27 (IL27) interaction partners

  1. The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).

蛋白简介IL27

蛋白简介

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).

Gene names and symbols associated with Interleukin 27 蛋白 (IL27)

  • interleukin 27 (IL27)
  • interleukin 27 (Il27)
  • IL-27 蛋白
  • IL-27A 蛋白
  • IL-27p28 蛋白
  • IL27 蛋白
  • IL27A 蛋白
  • IL27p28 蛋白
  • Il30 蛋白
  • p28 蛋白
  • RGD1561420 蛋白

Protein level used designations for Interleukin 27 蛋白 (IL27)

IL-27 p28 subunit , IL-27 subunit alpha , IL-27-A , IL27-A , interleukin 30 , interleukin-27 subunit alpha , interluekin 27 , interleukin 27 , interleukin 27 p28 subunit , p28

GENE ID SPECIES
246778 Homo sapiens
365368 Rattus norvegicus
607880 Canis lupus familiaris
614927 Bos taurus
737725 Pan troglodytes
246779 Mus musculus
493187 Sus scrofa
100349321 Oryctolagus cuniculus
100724612 Cavia porcellus
101122495 Ovis aries
101093822 Felis catus
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