Use your antibodies-online credentials, if available.
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. 再加上，我们可以发HSBP1 蛋白 (13) 和 HSBP1 试剂盒 (7)和数多这个蛋白质的别的产品。
Showing 10 out of 36 products:
Cow (Bovine) Polyclonal HSBP1 Primary Antibody for WB - ABIN2776380
Tai, McFall, Huang, Demeler, Fox, Brubaker, Radhakrishnan, Morimoto: Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain. in The Journal of biological chemistry 2002
HSPB1 protects cells against proapoptotic agents when expressed at high level, while inhibition of its expression has been found to predispose cells to apoptosis.
Results presented here show that acquisition of a positive charge in HSBP1, either by protonation of His124 or its substitution by lysine, reduces the stability of the dimer interface of the alpha-crystallin domain, increases oligomeric size, and modestly increases chaperone activity.
HSBP1 is crucial for regulating resistance to radiotherapy of oral squamous epithelial carcinoma cells by inducing stem-like status.
HspBP1 inhibited the cytotoxic activity of the Tag7-Hsp70 complex secreted by lymphocytes. HspBP1
This study reports the crystal structure of a degradation-resistant fragment of HSBP1. A continuous, long-helix conformation of HSBP1 assembles into a coiled-coil three-helix bundle and subsequently into an elongated, symmetrical hexamer.
HSBP likely mediates its function through its trimerization domain.
The effect of H2H2 haplotype combination on thermo tolerance traits major due to the single nucleotide pomylorphism of g.651C>G of HSBP1.
HSBP1 plays an essential role during early mouse and zebrafish embryonic development; lack of hsbp1 in embryoid bodies leads to disorganization of the germ layers and a reduction in the endoderm-specific markers.
In embryonic mandibles, chondrocytes in the anterior and intermediate portions of Meckel's cartilage showed Hsp25 immunoreactivity from the 12th day of gestation (E12) through E15.
loss of z-disk and membrane scaffolding proteins immediately after lengthening contractions, and concomitant translocation of HSP25 and alphaB-crystallin to the z-disk, which may help to stabilize or repair cytoskeletal elements at this site.
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.
heat shock factor binding protein 1
, Heat shock factor binding protein 1
, heat shock factor-binding protein 1
, heat shock factor binding protein 1 a
, nasopharyngeal carcinoma-associated antigen 13