Use your antibodies-online credentials, if available.
The enzyme encoded by GLO1 is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. 再加上，我们可以发Glyoxalase I 试剂盒 (28) 和 Glyoxalase I 蛋白 (24)和数多这个蛋白质的别的产品。
Showing 10 out of 143 products:
Human Monoclonal GLO1 Primary Antibody for IC, IF - ABIN2451990
Hovatta, Tennant, Helton, Marr, Singer, Redwine, Ellison, Schadt, Verma, Lockhart, Barlow: Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. in Nature 2005
Show all 3 Pubmed References
Human Polyclonal GLO1 Primary Antibody for ELISA, WB - ABIN561054
Sato, Kwon, Kamisuki, Srivastava, Mao, Kawazoe, Uesugi: Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. in Journal of the American Chemical Society 2007
Show all 2 Pubmed References
Human Monoclonal GLO1 Primary Antibody for ELISA, ICC - ABIN449661
Mailankot, Padmanabha, Pasupuleti, Major, Howell, Nagaraj: Glyoxalase I activity and immunoreactivity in the aging human lens. in Biogerontology 2011
Show all 2 Pubmed References
Human Polyclonal GLO1 Primary Antibody for ICC, IF - ABIN441467
Gabriele, Lombardi, Sacco, Napolioni, Altieri, Tirindelli, Gregorj, Bravaccio, Rousseau, Persico: The GLO1 C332 (Ala111) allele confers autism vulnerability: family-based genetic association and functional correlates. in Journal of psychiatric research 2014
Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.
Induced Glyoxalase 1 expression is a common feature in the pathogenesis of oropharyngeal squamous cell carcinoma
The lowering of glycative stress via modulation of RAGE (显示 AGER 抗体)-AGE axis or glyoxalase 1 activity is beneficial for tubular homeostasis and the subsequent prevention and treatment of kidney disease, suggesting the possibility of novel therapeutic approaches which target glycative stress.
Glo-1 responds to dicarbonyl stress to enhance cytoprotection at the transcriptional level through stress-responsive increase of Glo-1 expression.
Glo1, together with Glo2 (显示 HAGH 抗体), represents a novel mechanism in prostate cancer progression driven by a PTEN (显示 PTEN 抗体)/PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体)/mTOR (显示 FRAP1 抗体) signaling pathway.
Gly82Ser and 2184 A/G RAGE (显示 AGER 抗体) polymorphisms were related to the mortality due to the breast cancer and -419 A/C glyoxalase I polymorphism was related to the overall mortality of the patients suggesting their role not only in the risk of breast cancer but also in the outcome of patients with breast cancer.
Reduction of GLO1 activity in atherosclerotic lesions of nondiabetic patients with increased HbA1c is associated with a functional involvement of this protective enzyme in atherogenesis.
Studies suggest that the enhancement of glyoxalase I (GLO-1) is a promising strategy aimed at halting the vicious cycle between chronic kidney disease and increases in glycative stress.
GLO1 on one hand is crucial to maintaining tumor characteristics of malignant cells, and, on the other hand, supports malignant transformation of cells in a hypoxic environment when overexpressed.
GLO1 SNPs are significantly associated with late-onset and drug-resistant epilepsy.
Transgenic mice overexpressing Glo1 on both FVB/NJ (FVB) or C57BL/6J (B6) backgrounds showed increased voluntary EtOH consumption compared to their wild-type littermates. Transgenic Glo1 knockdown mice on a B6 background showed decreased voluntary EtOH consumption. Genetic manipulations of Glo1 had no effect on sucrose, saccharin or water consumption.
the Glo1-methylglyoxal pathway integrates maternal and neural precursor cell metabolism to regulate neural development.
These data indicate that Glo1 knockout reduces anxiety-like behavior, but increases depression-like behavior.
Alternative detoxification of methylglyoxal in GLO1(-/-) is achieved by increased catalytic efficiency of aldose reductase (显示 AKR1B1 抗体) toward hemithioacetal (product of glutathione and methylglyoxal ), which is most likely caused by S-nitrosylation of aldose reductase (显示 AKR1B1 抗体).
Glo1 knockdown does not have major short term effects on the energy expenditure or the formation of atherosclerotic plaques.
Crystal structure of the mouse Glo1-inhibitor complex was determined at 2.3 A resolution.
Study demonstrates that GLO1 is a novel metabolic oncogene (显示 RAB1A 抗体) of the 6p21 amplicon, which promotes tumor growth and aberrant transcriptional signals via regulating cellular metabolic activities for energy production.
the balance between methylglyoxal and age-dependent GLO1 downregulation contributes to delayed wound healing in old mice
The difference in glyoxalase-1 mRNA was observed with Fkbp5 (显示 FKBP5 抗体)-/- mice expressing 2-fold more glyoxylase-1 protein.
pharmacological inhibition of GLO1 reduced anxiety, suggesting that GLO1 is a possible target for the treatment of anxiety disorders.
The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere.
S-D-lactoylglutathione methylglyoxal lyase
, glx I
, glyoxalase domain containing 1
, ketone-aldehyde mutase
, lactoyl glutathione lyase
, lactoylglutathione lyase
, glyoxalase 1 complex
, glyoxalase 1 regulatory
, glyoxalase 1 structural
, glyoxalase I
, hypothetical protein
, trypanothione-dependent glyoxalase I
, glyoxylase 1