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GPRASP1 encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. 再加上，我们可以发G Protein-Coupled Receptor Associated Sorting Protein 1 抗体 (40) 和 G Protein-Coupled Receptor Associated Sorting Protein 1 试剂盒 (14)和数多这个蛋白质的别的产品。
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present the First low resolution solution structure of myostatin-free and myostatin-bound states of GASP-1 and GASP-2
Gasp-1 overexpression resulted in increased myostatin expression.
GASP-1 and GASP-2 are important modulators of GDF-11 and MSTN activity in vivo.
Overexpression of Gasp1 led to an increase in muscle mass observed not before day 15 of postnatal life.
The pattern of behavioral deficits observed in GASP-1-deficient mice is coherent with current knowledge of the role of striatal G protein-coupled receptor(GPCR)s in acquisition/expression of skilled behavior and motivation.
Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1
Data suggest that specific serine/threonine residues in DRD2 (dopamine receptor D2) are involved in regulation of DRD2 endocytosis by GRK2 (G-protein coupled receptor kinase 2) and GASP1.
GASP1 was identified as a potential new serum and biomarker for brain, pancreatic, lung, and breast cancers, and gliomas.
GASP-1 is a key regulator of the trafficking and, by extension, functional expression of GPR55
LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression.
These studies identify GASP-1 as a potential new serum and tumor biomarker for breast cancer.
following this endocytosis the D(3) dopamine receptors fail to recycle and are instead targeted for degradation through an interaction with the G protein-coupled receptor (GPCR)-associated sorting protein-1 (GASP-1)
This review describes the discovery of GASPs, their major features, interacting partners, functions and possible involvement in pathological situations including neurodegenerative diseases and cancer.
identified a protein that binds preferentially to the cytoplasmic tail of the delta opioid receptor as a candidate heterotrimeric GTP-binding protein (G protein)-coupled receptor-associated sorting protein (GASP) [GASP]
Modulation of the D2-GASP interaction is important for the functional down-regulation of D2 dopamine receptors.
This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified.
G-protein coupled receptor-associated sorting protein 1
, Per1 interacting protein
, per1-interacting protein
, G protein-coupled receptor associated sorting protein 1
, G-protein coupled receptor-associated sorting protein 1-like