Granulin 蛋白
(Granulin (GRN))
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| Granulin Protein (GRN) (AA 494-593) (GST tag) | 人 | 小麦胚 |
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| Granulin Protein (GRN) (AA 289-426) (His-IF2DI Tag) | 人 | 大肠杆菌（E. Coli） |
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| Granulin Protein (GRN) (AA 364-430) (His-IF2DI Tag) | 人 | 大肠杆菌（E. Coli） |
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| Granulin Protein (GRN) (His tag) | 小鼠 | HEK-293 Cells |
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| Granulin Protein (GRN) (AA 1-593) (GST tag) | 人 | 小麦胚 |
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| Granulin Protein (GRN) (AA 18-593) (His-Fc tag) | 人 | Mammalian Cells |
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| Granulin Protein (GRN) (AA 1-593, C-Term) (DYKDDDDK Tag) | 人 | HEK-293 Cells |
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| Granulin Protein (GRN) (AA 1-589) | 小鼠 | HEK-293 Cells |
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| Granulin Protein (GRN) (AA 1-593) | 人 | HEK-293 Cells |
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| Granulin Protein (GRN) (AA 1-602) | 大鼠 | HEK-293 Cells |
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| Granulin Protein (GRN) (AA 1-602, C-Term) (DYKDDDDK Tag) | 大鼠 | HEK-293 Cells |
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| Granulin Protein (GRN) (AA 1-593) (His tag) | 人 | HEK-293 Cells |
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| Granulin Protein (GRN) (AA 21-120) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| Granulin Protein (GRN) (AA 31-269) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| Granulin Protein (GRN) (AA 361-585) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| Granulin Protein (GRN) (AA 234-419) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| Granulin Protein (GRN) (AA 44-255) (His tag,GST tag) | 大鼠 | 大肠杆菌（E. Coli） |
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| Granulin Protein (GRN) (AA 361-585) (His tag,SUMO Tag) | 人 | 大肠杆菌（E. Coli） |
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| Granulin Protein (GRN) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| Granulin Protein (GRN) (Myc-DYKDDDDK Tag) | 人 | HEK-293 Cells |
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Protein
- AP (Affinity Purification: 所列应用)
- AA (Antibody Array: 所列应用)
- ELISA (ELISA: 所列应用)
- WB (Western Blotting: 所列应用)
3 references - 宿主
- 人
- 宿主
- 小麦胚
- 蛋白类型
- Recombinant
Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 有验证图片)
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- ELISA (ELISA: 所列应用)
- AcA (Activity Assay: 所列应用)
- 宿主
- 人
- 宿主
- Mammalian Cells
- 蛋白类型
- Recombinant
- 纯度
- >90 % as determined by SDS-PAGE.
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >98 % (SDS-PAGE)
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 所列应用)
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >95 % (SDS-PAGE)
Protein
- SDS (SDS-PAGE: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >98 % (SDS-PAGE)
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 所列应用)
- 宿主
- 大鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >95 % (SDS-PAGE)
Protein
- SDS (SDS-PAGE: 所列应用)
- 宿主
- 大鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >95 % (SDS-PAGE)
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 大鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- SDS (SDS-PAGE: 有验证图片)
- WB (Western Blotting: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- WB (Western Blotting: 有验证图片)
- AbP (Antibody Production: 所列应用)
- STD (Standard: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Latest Publications for our Granulin 蛋白
: "Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer." in: Oncotarget, Vol. 8, Issue 16, pp. 26323-26333, (2018) (PubMed).
: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." in: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).
: "Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 21, pp. 9202-13, (2013) (PubMed).
: "The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding." in: Neurobiology of aging, Vol. 34, Issue 11, pp. 2541-7, (2013) (PubMed).
: "Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival." in: The Journal of cell biology, Vol. 181, Issue 1, pp. 37-41, (2008) (PubMed).
: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." in: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).
: "Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 21, pp. 9202-13, (2013) (PubMed).
: "The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding." in: Neurobiology of aging, Vol. 34, Issue 11, pp. 2541-7, (2013) (PubMed).
: "Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival." in: The Journal of cell biology, Vol. 181, Issue 1, pp. 37-41, (2008) (PubMed).
Aliases for Granulin 蛋白
granulin precursor (GRN) 蛋白granulin a (grna) 蛋白
Granulins (grn) 蛋白
granulin L homeolog (grn.L) 蛋白
granulin (granulin) 蛋白
granulin (ORF1 granulin) 蛋白
granulin precursor (Grn) 蛋白
granulin (Grn) 蛋白
acrogranin 蛋白
CLN11 蛋白
DKFZp459H066 蛋白
epithelin 蛋白
GEP 蛋白
GP88 蛋白
GRN 蛋白
grn 蛋白
MGC53354 蛋白
PCDGF 蛋白
PEPI 蛋白
PGRN 蛋白
wu:fb11g12 蛋白
wu:fj18f05 蛋白
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