Eukaryotic Translation Initiation Factor 1A, X-Linked 蛋白 (EIF1AX)

EIF1AX encodes an essential eukaryotic translation initiation factor. 再加上,我们可以发EIF1AX 抗体 (26)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
大鼠 EIF1AX EIF1AX 302697  
EIF1AX 66235 Q8BMJ3
EIF1AX 1964 P47813
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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大肠杆菌(E. Coli) His tag   50 μg Log in to see 4 Days
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大肠杆菌(E. Coli) His tag Validation with Western Blot 50 μg Log in to see Available
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至19个工作日
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大肠杆菌(E. Coli) His tag   10 μg Log in to see 15至16个工作日
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非结合性   1 mg Log in to see 6 Days
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EIF1AX 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine)

Human ,
,

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Human Eukaryotic Translation Initiation Factor 1A, X-Linked (EIF1AX) interaction partners

  1. Its mutation is found in patients with meningeal melanocytic tumor.

  2. Study identified a new RNA-induced silencing complex component, eIF1A, which directly interacts with the MID-domain of Ago2 and functions in DICER-independent miRNA biogenesis and miRNA-mediated RNA interference.

  3. EIF1AX alterations occurred infrequently in low-grade gliomas (1.4%), uterus endometrial carcinoma (1.25%), thyroid carcinoma (1%), and lung adenocarcinoma (0.4%).

  4. In this report we show that patients with uveal melanoma harbor mutation-specific chromosomal patterns in the tumor. These chromosomal patterns are characterized by different types of chromosomal anomalies, thus illustrating that distinct biological mechanisms underlie uveal melanoma pathogenesis.

  5. Coexpression of mutant NRAS and EIF1AX proteins promoted proliferation and clonogenic survival in LGSC cells, providing the first example of co-occurring, growth-promoting mutational events in ovarian cancer.

  6. Short 5'UTR mRNAs are enriched with TISU (translation initiator of short 5'UTR), a 12-nucleotide element directing efficient scanning-independent translation. This study demonstrate that TISU is particularly dependent on eukaryotic initiation factor 1A (eIF1A) which interacts with both RPS3 and RPS10e.

  7. Mutation in EIF1AX gene is associated with Uveal Melanoma.

  8. we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ, GNA11, and EIF1AX mutations.

  9. results indicate that the interactions between eIF1A and eIF5B are being continuously rearranged during translation initiation; presentation of a model how the dynamic eIF1A/eIF5B interaction network can promote remodeling of the translation initiation complexes, and the roles in the process played by intrinsically disordered protein segments

  10. Patients with uveal melanoma can be classified into 3 groups, of which EIF1AX-mutated tumors and tumors without BAP1, SF3B1, or EIF1AX mutations are associated with prolonged survival and low metastatic risk, SF3B1-mutated tumors are associated with late metastasis

  11. BAP1, SF3B1, and EIF1AX mutations occur during uveal melanoma tumor progression in an almost mutually exclusive manner and are associated with different levels of metastatic risk.

  12. We report here the occurrence of EIF1AX mutations not only in thyroid cancer, but also in benign thyroid nodules, and demonstrate that phenotypically these mutations are associated with the encapsulated follicular variant of papillary thyroid carcinoma and benign follicular-pattern nodules.

  13. The finding of this study suggested that an SF3B1 or EIF1AX mutation is present in a substantial subset of primary LMNs underscores that these tumors genetically resemble uveal melanoma and are different from cutaneous melanoma at the genetic level.

  14. Then, activated p38 further enhanced the docking of activating transcription factor 4 (ATF4) onto the CHOP (CCAAT/enhancer-binding protein homologous protein) promoter via eIF2alpha to enhance apoptosis

  15. The effect of an EIF1AX mutation is estimated to be a decreased odds of metastasis in uveal melanoma.

  16. the newly identified driver mutations in EIF1AX and SF3B1, specifically found in uveal melanomas with disomy 3, confirm and extend the established classification model of uveal melanoma.

  17. Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex

  18. eIF3j/HCR1 closely cooperates with the eIF3b/PRT1 RNA recognition motif and eIF1A on the ribosome to ensure proper formation of the scanning-arrested conformation required for stringent AUG recognition

  19. Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers.

  20. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.

Cow (Bovine) Eukaryotic Translation Initiation Factor 1A, X-Linked (EIF1AX) interaction partners

  1. molecular network including eIF1AX, RPS7, and 14-3-3gamma regulates protein translation and cell proliferation in BMECs.

蛋白简介EIF1AX

蛋白简介

This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.

Gene names and symbols associated with EIF1AX

  • eukaryotic translation initiation factor 1A, X-linked (Eif1ax)
  • eukaryotic translation initiation factor 1A, X-linked (EIF1AX)
  • eukaryotic translation initiation factor 1A, X-linked S homeolog (eif1ax.S)
  • eukaryotic translation initiation factor 1A, X-linked, a (eif1axa)
  • 1500010B24Rik 蛋白
  • AI426898 蛋白
  • eif-1a 蛋白
  • eif-4c 蛋白
  • eif1a 蛋白
  • eif1ap1 蛋白
  • eif1ax 蛋白
  • EIF1AY 蛋白
  • eif4c 蛋白
  • RGD1560198 蛋白
  • zgc:101670 蛋白

Protein level used designations for EIF1AX

eukaryotic translation initiation factor 1A, X-chromosomal , eukaryotic translation initiation factor 1A, Y-linked , eIF-1A X isoform , eIF-4C , eukaryotic translation initiation factor 4C , Putative eukaryotic translation initiation factor 1A , eukaryotic translation initiation factor 1A, X chromosome , eukaryotic translation initiation factor 1A, X-linked S homeolog

GENE ID SPECIES
302697 Rattus norvegicus
66235 Mus musculus
1964 Homo sapiens
444500 Xenopus laevis
450062 Danio rerio
100720954 Cavia porcellus
511189 Bos taurus
611715 Canis lupus familiaris
695456 Macaca mulatta
100270711 Ovis aries
100522912 Sus scrofa
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