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EIF1AX encodes an essential eukaryotic translation initiation factor. 再加上，我们可以发EIF1AX 抗体 (26) 和 和数多这个蛋白质的别的产品。
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Study identified a new RNA-induced silencing complex component, eIF1A, which directly interacts with the MID-domain of Ago2 (显示 EIF2C2 蛋白) and functions in DICER (显示 DICER1 蛋白)-independent miRNA biogenesis and miRNA-mediated RNA interference.
EIF1AX alterations occurred infrequently in low-grade gliomas (1.4%), uterus endometrial carcinoma (1.25%), thyroid carcinoma (1%), and lung adenocarcinoma (0.4%).
Coexpression of mutant NRAS (显示 NRAS 蛋白) and EIF1AX proteins promoted proliferation and clonogenic survival in LGSC cells, providing the first example of co-occurring, growth-promoting mutational events in ovarian cancer.
Short 5'UTR mRNAs are enriched with TISU (translation initiator of short 5'UTR), a 12-nucleotide element directing efficient scanning-independent translation. This study demonstrate that TISU is particularly dependent on eukaryotic initiation factor (显示 EIF4G1 蛋白) 1A (eIF1A) which interacts with both RPS3 (显示 RPS3 蛋白) and RPS10e.
Mutation in EIF1AX gene is associated with Uveal Melanoma.
we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ (显示 GNAQ 蛋白), GNA11 (显示 GNA11 蛋白), and EIF1AX mutations.
results indicate that the interactions between eIF1A and eIF5B (显示 EIF5B 蛋白) are being continuously rearranged during translation initiation; presentation of a model how the dynamic eIF1A/eIF5B (显示 EIF5B 蛋白) interaction network can promote remodeling of the translation initiation complexes, and the roles in the process played by intrinsically disordered protein segments
Patients with uveal melanoma can be classified into 3 groups, of which EIF1AX-mutated tumors and tumors without BAP1 (显示 RNF2 蛋白), SF3B1 (显示 SF3B2 蛋白), or EIF1AX mutations are associated with prolonged survival and low metastatic risk, SF3B1 (显示 SF3B2 蛋白)-mutated tumors are associated with late metastasis
BAP1 (显示 RNF2 蛋白), SF3B1 (显示 SF3B2 蛋白), and EIF1AX mutations occur during uveal melanoma tumor progression in an almost mutually exclusive manner and are associated with different levels of metastatic risk.
We report here the occurrence of EIF1AX mutations not only in thyroid cancer, but also in benign thyroid nodules, and demonstrate that phenotypically these mutations are associated with the encapsulated follicular variant of papillary thyroid carcinoma and benign follicular-pattern nodules.
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.
Putative eukaryotic translation initiation factor 1A
, eIF-1A X isoform
, eukaryotic translation initiation factor 1A, X chromosome
, eukaryotic translation initiation factor 1A, X-chromosomal
, eukaryotic translation initiation factor 4C
, eukaryotic translation initiation factor 1A, Y-linked