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ELOVL5 plays a role in elongation of long-chain polyunsaturated fatty acids (Leonard et al., 2000. 再加上，我们可以发和数多这个蛋白质的别的产品。
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This study investigated the expression of genes encoding enzymes involved in long-chain polyunsaturated fatty acids biosynthesis, namely fatty acyl desaturase (Fad (显示 PSEN1 抗体)) and Elovl5- and Elovl2 (显示 ELOVL2 抗体)-like elongases, during early embryonic development of zebrafish.
These studies establish that Elovl5 activity regulates hepatic levels of FAs (显示 FAS 抗体) controlling PPARbeta (显示 PPARD 抗体) activity, ATGL (显示 PNPLA2 抗体) expression, and TG catabolism, but not FA oxidation.
knockdown of Elovl5, Fads1 (显示 FADS1 抗体), or Fads2 (显示 FADS2 抗体) decreased the level of Mead acid.
a novel link between Elovl5-mediated synthesis of 18:1,n-7 and GNG through the control of the mTORC2 (显示 CRTC2 抗体)-Akt (显示 AKT1 抗体)-FoxO1 (显示 FOXO1 抗体) pathway
Results establish a link between fatty acid elongation and hepatic glucose metabolism and suggest a role for regulators of Elovl5 activity in the treatment of diet-induced hyperglycemia.
Elovl5-induced changes in hepatic fatty acid content affect multiple pathways regulating hepatic lipid and carbohydrate composition
reduced ELOVL5 activity leads to hepatic steatosis, and endogenously synthesized PUFAs are key regulators of SREBP-1c (显示 SREBF1 抗体) activation and fatty acid synthesis in liver
Low ELOVL5 expression is associated with colorectal cancer.
SCA38 subtype is very rare in Mainland China; no disease-related gene mutations in ELOVL5.
performed a detailed promoter/enhancer analysis of ELOVL5 gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1
In transfection experiments, subcellular localization of altered ELOVL5 showed a perinuclear distribution with a signal increase in the Golgi compartment, whereas the wild-type showed a widespread signal in the endoplasmic reticulum.
Changes in the mRNA-expression levels of FADS1 (显示 FADS1 抗体) and 2 directly affect blood DGLA levels and D6D (显示 FADS2 抗体) activity. This study suggests that lower mRNA-expressions of FADS2 (显示 FADS2 抗体) and ELOVL5 are associated with higher risk of atopic eczema in young children.
Typical POAG associated with ELOVL5 gene polymorphism may have a late rather than an early onset.
Not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele.
Our genome-wide association study identified SRBD1 and ELOVL5 as new susceptibility genes for (normal tension glaucoma) NTG (显示 OPA1 抗体).
we performed association analysis between the genotypes and traits and our result revealed that T allele of g.-110T>C in ELOVL5 gene promoter indicated significantly thinner subcutaneous fat thickness than that of C allele
ELOVL5 plays a role in elongation of long-chain polyunsaturated fatty acids (Leonard et al., 2000
elongation of very long chain fatty acids protein 5
, ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
, elongation of long chain fatty acids family member 5
, elongation of very long chain fatty acids protein
, homolog of yeast long chain polyunsaturated fatty acid elongatio
, 3-keto acyl-CoA synthase Elovl5
, ELOVL FA elongase 5
, ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like)
, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
, elongation of very long chain fatty acids-like 2
, very-long-chain 3-oxoacyl-CoA synthase 5
, 3-keto acyl-CoA synthase ELOVL5
, ELOVL fatty acid elongase 5
, fatty acid elongase 1
, homolog of yeast long chain polyunsaturated fatty acid elongation enzyme
, homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2
, ELOVL family member 5, elongation of long chain fatty acids
, elongation of very long chain fatty acids-like 5
, 3-keto acyl-CoA synthase elovl5