Cytokine Receptor-Like Factor 2 蛋白 (CRLF2)

The protein encoded by CRLF2 is a receptor for thymic stromal lymphopoietin (TSLP). 再加上,我们可以发CRLF2 抗体 (131)CRLF2 试剂盒 (9)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CRLF2 64109 Q9HC73
CRLF2 57914 Q8CII9
CRLF2 171499  
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50至55个工作日
$5,355.45
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Baculovirus infected Insect Cells His tag 50 μg Log in to see 13至16个工作日
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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人细胞 小鼠 Fc Tag   50 μg Log in to see 4 Days
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至19个工作日
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酵母菌 大鼠 His tag   1 mg Log in to see 60至71个工作日
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人细胞 小鼠 His tag   10 μg Log in to see 15至16个工作日
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HEK-293 Cells Fc Tag   100 μg Log in to see 5 Days
$385.00
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CRLF2 蛋白 by Origin and Source

Origin 在表达 标记
Human , , , ,
, , , ,
Mouse (Murine) ,
, ,
Rat (Rattus)

更多Cytokine Receptor-Like Factor 2 (CRLF2)互动伙伴

Human Cytokine Receptor-Like Factor 2 (CRLF2) interaction partners

  1. Family-based whole genome analysis of a family with hereditary pulmonary alveolar proteinosis revealed a homozygous deletion that disrupts CSF2RA (显示 CSF2RA 蛋白), CRLF2, and IL3RA (显示 IL3RA 蛋白) gene in the pseudoautosomal region of the X chromosome in the affected child and one of asymptomatic siblings.

  2. TSLP (显示 TSLP 蛋白) expression on the basophil membrane of patients with severe asthma was not significantly different from healthy controls.

  3. high CRLF2 expression works with the IKZF1 deletion to drive oncogenesis of acute lymphoblastic leukemia

  4. this study shows that CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia

  5. data suggest that this high frequency of genetic aberrations in the context of a high CRLF2 expression could contribute to the high risk of relapse in P2RY8 (显示 P2RY8 蛋白)/CRLF2- and IGH/CRLF2-positive acute lymphoblastic leukemia.

  6. CRLF2 overexpression is associated with childhood B-cell acute lymphoblastic leukemia.

  7. CRLF2 gene rearrangement is associated with acute lymphoblastic leukemia.

  8. TSLPR levels were found to be significantly higher in asthmatic than in nonasthmatic children. TSLPR expression in non-allergic asthmatic and allergic asthmatic groups was found to be significantly higher than in non-allergic nonasthmatic group

  9. In adult B-cell acute lymphoblastic leukemia without recurrent fusion genes , high CRLF2 expression is associated with distinct clinico-biological features and an unfavourable prognosis

  10. CD4 (显示 CD4 蛋白)+ T cells from atopic dermatitis patients directly interacted with TSLP (显示 TSLP 蛋白) to produce a higher amount of IL-4 (显示 IL4 蛋白) than those from normal subjects, and this action was attenuated with anti-TSLPR antibody

Mouse (Murine) Cytokine Receptor-Like Factor 2 (CRLF2) interaction partners

  1. these results suggest that TSLP (显示 TSLP 蛋白)-TSLPR signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection

  2. A novel mouse xenograft model to study the role of TSLP (显示 TSLP 蛋白)-induced CRLF2 (显示 CRLF3 蛋白) signals in normal and malignant human B lymphopoiesis has been developed.

  3. High-cholesterol diet increased TSLPR expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR, potentially through the PI3K/Akt (显示 AKT1 蛋白) signal pathway.

  4. Activating thymic stromal lymphopoietin (显示 TSLP 蛋白) promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR signaling in a mouse model.

  5. Suggest that Treg defects in ApoE (显示 APOE 蛋白)(-/-) mice might partially be attributed to the disruption of TSLP (显示 TSLP 蛋白)-TSLPR-LAP signaling in epithelial cells and dendritic cells.

  6. The structure of the mouse TSLP (显示 TSLP 蛋白)-mediated signaling complex reveals how TSLP (显示 TSLP 蛋白) establishes extensive interfaces with its cognate receptor (TSLPR).

  7. TSLPR helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells.

  8. A previously unrecognized role was found for TSLP (显示 TSLP 蛋白)/TSLPR signaling in type 2 immunity as an important enhancer for the development of alternately activated macrophages as well as for chemokine (显示 CCL1 蛋白) production.

  9. mice deficient in TSLP receptors on LCs abrogated the induction of OVA-specific IgE levels upon epicutaneous OVA sensitization.

  10. Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice.

蛋白简介CRLF2

蛋白简介

The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CRLF2

  • cytokine receptor like factor 2 (CRLF2)
  • cytokine receptor-like factor 2 (Crlf2)
  • Crl2 蛋白
  • CRLF2 蛋白
  • CRLF2Y 蛋白
  • CRLM2 蛋白
  • Ly114 蛋白
  • Tpte2 蛋白
  • Tslpr 蛋白

Protein level used designations for CRLF2

cytokine receptor-like factor 2 , IL-XR , P2RY8/CRLF2 fusion , TSLP receptor , cytokine receptor CRL2 precusor , cytokine receptor-like 2 , thymic stromal lymphopoietin protein receptor , thymic stromal lymphopoietin receptor , thymic stromal-derived lymphopoietin receptor , CRLM-2 , cytokine receptor-like molecule 2 , delta 1 , lymphocyte antigen 114 , thymic stromal-derived lymphopoietin, receptor , transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 , type I cytokine receptor delta 1

GENE ID SPECIES
491709 Canis lupus familiaris
529792 Bos taurus
749758 Pan troglodytes
100582238 Nomascus leucogenys
64109 Homo sapiens
57914 Mus musculus
171499 Rattus norvegicus
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