Chloride Channel 5 蛋白 (CLCN5)

CLCN5 encodes a member of the ClC family of chloride ion channels and ion transporters. 再加上,我们可以发Chloride Channel 5 抗体 (64)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
CLCN5 12728 Q9WVD4
CLCN5 1184 P51795
大鼠 CLCN5 CLCN5 25749 P51796
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大肠杆菌(E. Coli) His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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大肠杆菌(E. Coli) 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30至35个工作日
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60至65个工作日
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Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 60至65个工作日
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小麦胚 GST tag 2 μg Log in to see 11至12个工作日
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CLCN5 蛋白 by Origin and Source

Origin 在表达 标记
Mouse (Murine) ,
,
Human , ,
, ,

引用最多的Chloride Channel 5 蛋白

  1. Human Chloride Channel 5 Protein expressed in Wheat germ - ABIN1349570 : Hryciw, Jenkin, Simcocks, Grinfeld, McAinch, Poronnik: The interaction between megalin and ClC-5 is scaffolded by the Na?-H? exchanger regulatory factor 2 (NHERF2) in proximal tubule cells. in The international journal of biochemistry & cell biology 2012 (PubMed)

更多Chloride Channel 5 (CLCN5)互动伙伴

Xenopus laevis Chloride Channel 5 (CLCN5) interaction partners

  1. analysis of extracellular determinants of anion discrimination of the Cl-/H+ antiporter protein CLC-5

Mouse (Murine) Chloride Channel 5 (CLCN5) interaction partners

  1. This study demonistrated that Clcn5 gene expression in mouse dorsal raphe nucleus

  2. ClC-5 plays an essential role in exocytosis of NHE3 (显示 SLC9A3 蛋白).

  3. HNF1alpha (显示 HNF1A 蛋白) directly regulates the expression of ClC-5 in the renal proximal tubule

  4. ClC-5 is unique among CLC (显示 CLC 蛋白) proteins in being crucial for proximal tubular endocytosis and the PY-motif-dependent ubiquitylation of ClC-5 is dispensable for this rol

  5. findings show that endosomal chloride concentration, which is raised by ClC-5 in exchange for protons accumulated by H+-ATPase (显示 ATP6AP1 蛋白), may play a role in endocytosis

  6. Our studies demonstrate a role for CLC-5 in the immunopathogenesis of ulcerative colitis

  7. ClC-5 regulates dentin development through TGF-beta1 (显示 TGFB1 蛋白) pathway

  8. Disruption of CLC-5 expression causes abnormal calcium crystal agglomeration on the surface of kidney collecting duct cells.

  9. hypercalciuria in the ClC-5 KO mice on low and high calcium diets is of bone and renal origin and is not caused by increased intestinal calcium absorption

  10. Impaired protein endocytosis caused by invalidation of ClC-5 primarily reflects a trafficking defect of megalin (显示 LRP2 蛋白) and cubilin (显示 CUBN 蛋白) in PTC (显示 PTCH1 蛋白).

Human Chloride Channel 5 (CLCN5) interaction partners

  1. We demonstrated that most Polish patients with DD carry CLCN5 mutations, and they usually present with proteinuria and hypercalciuria.

  2. Novel CLCN5 (c.1205G>A, p.W402*) and FGF23 (显示 FGF23 蛋白) (c.526C>G, p.R176G) mutations were found in two patients from the remaining two families

  3. Expression of ClC-5 carrying Dent's disease-associated mutations in HEK293 cells had varying effects: (1) no detectable expression of mutant protein; (2) retention of a truncated protein in the endoplasmic reticulum; or (3) diminished protein expression with normal distribution in early endosomes.

  4. These data suggest that ClC-5 enhances the cytotoxic action of Clostridium difficile toxins TcdA and TcdB by accelerating the acidification and maturation of vesicles of the early and early-to-late endosomal system.

  5. A diagnosis of Dent disease was established in 19 boys from 16 families by the presence of loss of function/deleterious mutations in CLCN5 or OCRL1 (显示 OCRL 蛋白).

  6. we carefully investigated the functional effects of four CLC-5 mutations, including three missense mutations (S244L, R345W, T657S) and one nonsense mutation (Q629X)

  7. A novel mutation in the CLCN5 gene was identified in our patient with Dent's disease.

  8. structural complexity of the CLCN5 5'UTR region

  9. ATP induces conformational changes in the carboxyl-terminal region of ClC-5.

  10. study described a single Chinese family with Dent disease, and findings suggest that a novel frameshift mutation (c. 246delG) in exon 5 of the CLCN5 gene was responsible for Dent disease in this case

蛋白简介Chloride Channel 5 (CLCN5)

蛋白简介

This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with Chloride Channel 5 蛋白 (CLCN5)

  • chloride voltage-gated channel 5 (CLCN5)
  • chloride channel, voltage-sensitive 5 L homeolog (clcn5.L)
  • chloride channel, voltage-sensitive 5 (clcn5)
  • chloride channel, voltage-sensitive 5 (Clcn5)
  • chloride voltage-gated channel 5 (Clcn5)
  • 5430408K11Rik 蛋白
  • ClC-5 蛋白
  • CLC5 蛋白
  • CLCK2 蛋白
  • CLCN3 蛋白
  • CLCN4 蛋白
  • Clcn5 蛋白
  • clcn5-A 蛋白
  • D930009B12Rik 蛋白
  • DENTS 蛋白
  • DKFZp469O2315 蛋白
  • DXImx42e 蛋白
  • hCIC-K2 蛋白
  • NPHL1 蛋白
  • NPHL2 蛋白
  • Sfc13 蛋白
  • T25545 蛋白
  • XLRH 蛋白
  • XRN 蛋白

Protein level used designations for Chloride Channel 5 蛋白 (CLCN5)

chloride channel 5 (nephrolithiasis 2, X-linked, Dent disease) , chloride channel protein 5 , chloride channel 5 , H(+)/Cl(-) exchange transporter 5-like , Chloride channel protein 5 , H(+)/Cl(-) exchange transporter 5 , chloride transporter ClC-5 , voltage-gated chloride ion channel CLCN5 , clC-5 , chloride channel CLC-5 , chloride channel CLCN5 , chloride channel Clc-5

GENE ID SPECIES
493644 Bos taurus
422285 Gallus gallus
491882 Canis lupus familiaris
394306 Xenopus laevis
694497 Macaca mulatta
734069 Xenopus (Silurana) tropicalis
100410688 Callithrix jacchus
100174406 Pongo abelii
100581324 Nomascus leucogenys
12728 Mus musculus
1184 Homo sapiens
25749 Rattus norvegicus
100008741 Oryctolagus cuniculus
100135502 Cavia porcellus
397263 Sus scrofa
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