Chemokine (C-C Motif) Receptor-Like 2 蛋白 (CCRL2)

CCRL2 encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. 再加上,我们可以发CCRL2 抗体 (101)CCRL2 试剂盒 (2)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
大鼠 CCRL2 CCRL2 316019  
CCRL2 9034 O00421
CCRL2 54199 O35457
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产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50至55个工作日
$7,626.01
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Insect Cells 小鼠 rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50至55个工作日
$5,355.45
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小麦胚 GST tag 2 μg Log in to see 11至12个工作日
$338.33
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小麦胚 非结合性   2 μg Log in to see 11至12个工作日
$491.43
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CCRL2 蛋白 by Origin and Source

Origin 在表达 标记
Human ,
,
Mouse (Murine)

更多Chemokine (C-C Motif) Receptor-Like 2 (CCRL2)互动伙伴

Human Chemokine (C-C Motif) Receptor-Like 2 (CCRL2) interaction partners

  1. CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 mRNA levels were positively correlated with inflammation, fibrosis and NASH scores in the patients.

  2. CCRL2 inhibited the growth of breast cancer cells in vitro and in vivo.

  3. in breast cancer, CRAM-A becomes specifically upregulated under inflammatory stimuli and may serve as a potential marker of immune response.

  4. these results suggest for the first time that elevated CCRL2 in glioma promotes cell migration and invasion.

  5. Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect pneumocystis pneumonia through immune regulation and inducing inflammation.

  6. demonstration that the homeostatic chemokine CCL19 (显示 CCL19 蛋白) is a specific ligand for CRAM

  7. CCRL2 expression is up-regulated on synovial neutrophils of rheumatoid arthritis patients

  8. Results identify chemerin (显示 RARRES2 蛋白) as a natural nonsignaling protein ligand for both human and mouse CCRL2.

Mouse (Murine) Chemokine (C-C Motif) Receptor-Like 2 (CCRL2) interaction partners

  1. Ccrl2 modulates chemerin (显示 RARRES2 蛋白) levels in the epithelial lining fluid of the lungs but does not contribute to the development of O3-induced lung pathology.

  2. upregulation of CCRL2 observed under inflammatory conditions is functional to finely tune CXCR2 (显示 CXCR2 蛋白)-mediated neutrophil recruitment at sites of inflammation.

  3. chemokine (CC motif) receptor-like 2 should be considered to be a molecule involved in the regulation of the inflammatory response associated with multiple sclerosis.

  4. CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 was related to the mRNA levels of F4/80, transforming growth factor beta and alpha smooth muscle actin (显示 ACTG2 蛋白) in murine non-alcoholic steatohepatitis.

  5. Proinflammatory stimuli upregulate atypical chemerin receptor (显示 CMKLR1 蛋白) CCRL2 and VCAM-1 (显示 VCAM1 蛋白) on endothelial cells via NF-kappaB (显示 NFKB1 蛋白) and JAK (显示 JAK3 蛋白)/STAT (显示 STAT1 蛋白) intracellular signaling pathways.

  6. Ccrl2(-/-) mice showed normal recruitment of circulating dendritic cells (DC) into the lung, but a defective trafficking of antigen-loaded lung DC to mediastinal lymph nodes.

  7. Expression of L-CCR mRNA is reported in murine astrocytes and microglia and is greatly enhanced under proinflammatory conditions; this receptor may play a role in neuroinflammatory processes.

  8. Prominent expression of L-CCR mRNA is detected in astrocytes and microglia at early time points throughout the brain and spinal cord in experimental autoimmune encephalomyelitis supporting the proposed relationship of L-CCR expression to CNS inflammation.

  9. Results identify chemerin (显示 RARRES2 蛋白) as a natural nonsignaling protein ligand for both human and mouse CCRL2.

蛋白简介CCRL2

蛋白简介

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.

Gene names and symbols associated with CCRL2

  • C-C motif chemokine receptor like 2 (Ccrl2)
  • C-C motif chemokine receptor like 2 (CCRL2)
  • chemokine (C-C motif) receptor-like 2 (Ccrl2)
  • 1810047I05Rik 蛋白
  • Ackr5 蛋白
  • CCR11 蛋白
  • CCRL2 蛋白
  • CKRX 蛋白
  • Cmkbr1l2 蛋白
  • CRAM 蛋白
  • CRAM-A 蛋白
  • CRAM-B 蛋白
  • E01 蛋白
  • HCR 蛋白
  • L-CCR 蛋白

Protein level used designations for CCRL2

C-C chemokine receptor-like 2 , chemokine (C-C motif) receptor-like 2 , c-C chemokine receptor-like 2-like , atypical chemokine receptor 5 , chemokine receptor CCR11 , chemokine receptor X , putative MCP-1 chemokine receptor , G-protein coupled beta chemokine receptor , chemokine (C-C) receptor 1,-like 2 , chemokine (C-C) receptor 1-like 2 , lipopolysaccharide inducible C-C chemokine receptor related , lipopolysaccharide-inducible C-C chemokine receptor , lipopolysacharide-inducible C-C chemokine receptor , chemokine C-C motif receptor-like 2

GENE ID SPECIES
316019 Rattus norvegicus
460324 Pan troglodytes
484788 Canis lupus familiaris
100439180 Pongo abelii
100582482 Nomascus leucogenys
9034 Homo sapiens
54199 Mus musculus
414370 Sus scrofa
515976 Bos taurus
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