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Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. 再加上，我们可以发COX17 蛋白 (8) 和 和数多这个蛋白质的别的产品。
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Human Monoclonal COX17 Primary Antibody for IHC (p), ELISA - ABIN564350
Tokuda, Okawa, Watanabe, Ono, Marklund: Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities. in Neurobiology of disease 2013
These results collectively indicate that Cox17 might not participate in the action of these anticancer organoruthenium complexes, and further verify the distinct anticancer mechanism of the organoruthenium(II) complexes from cisplatin.
In addition to Atox1 (显示 ATOX1 抗体), the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (显示 SOD1 抗体) (i.e. CCS (显示 CCS 抗体)) and cytochrome c (显示 CYCS 抗体) oxidase in mitochondria (i.e. Cox17). [review]
Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17), mitochondrial membrane transport protein Mia40 (显示 CHCHD4 抗体) and superoxide dismutase 1 (SOD1 (显示 SOD1 抗体)) in the cytoplasm were directly observed with in-cell NMR spectroscopy.
Data suggest that Cox17 enhances the reactivity of some platinum/organoplatinum antineoplastic drugs but suppresses the reactivity of at least one platinum antineoplastic drug; glutathione modulates binding of platinum/organoplatinum drugs to Cox17.
CTR1 (显示 SLC31A1 抗体) silencing increased the protein levels of copper chaperone ATOX1 (显示 ATOX1 抗体) and copper chaperone for superoxide dismutase (显示 CCS 抗体) 1 (显示 SOD1 抗体) (CCS (显示 CCS 抗体)-1), but decreased copper chaperone for cytochrome c (显示 CYCS 抗体) oxidase (COX17).
Functional role of two interhelical disulfide bonds in human Cox17 protein from a structural perspective.
Data imply that up-regulation of COX17 function and increased cytochrome c (显示 CYCS 抗体) oxidase activity are frequent features of lung carcinogenesis.
The binding of copper to Cox17 is needed to activate cytochrome c (显示 CYCS 抗体) oxidase by Cox17.
Cox17-mediated copper metallation of Sco1, as well as the subsequent failure of Cu(A) site maturation, is the basis for the inefficient assembly of the cytochrome c oxidase complex in SCO1 patients
Cox17 was studied with regard to its expression, purification, and formation of mixed disulfide adducts with sulfhydryl reagents.
Sp1 (显示 SP1 抗体), NRF-1 (显示 NRF1 抗体) and NRF-2 (显示 NFE2L2 抗体) are involved in basal transcription, similar to the transcription mechanism of other CCO (显示 RYR1 抗体)-related genes
cox17 has a role in activating cytochrome c (显示 CYCS 抗体) oxidase in mice
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.
COX17 cytochrome c oxidase assembly homolog
, cytochrome c oxidase 17 copper chaperone
, cytochrome c oxidase assembly homolog 17
, cytochrome c oxidase copper chaperone
, human homolog of yeast mitochondrial copper recruitment
, cytochrome c oxidase subunit XVII assembly protein homolog
, cytochrome c oxidase, subunit XVII assembly protein homolog
, COX17 homolog, cytochrome c oxidase assembly protein
, COX17 cytochrome c oxidase assembly homolog (S. cerevisiae)
, COX17 homolog, cytochrome c oxidase assembly protein (yeast)