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The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. 再加上，我们可以发Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 抗体 (71)和数多这个蛋白质的别的产品。
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APPL1 positively mediated leptin (显示 LEP 蛋白) signaling.
Decreased expression of APPL1 is associated with polycystic ovary syndrome.
Results indicate that persistent rab5 (显示 RAB5A 蛋白) overactivation through beta-cleaved carboxy-terminal fragment of APP (显示 APP 蛋白)-APPL1 interactions constitutes a novel APP (显示 APP 蛋白)-dependent pathogenic pathway in Alzheimer's disease
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
Low expression of APPL1 is associated with metastasis in prostate cancer.
APPL1 endosomes represent a distinct population of Rab5 (显示 RAB5A 蛋白)-positive sorting endosomes.
article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD
Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.
A role for APPL1 in TLR3 (显示 TLR3 蛋白)/4-dependent TBK1 (显示 TBK1 蛋白) and IKKepsilon (显示 IKBKE 蛋白) activation in macrophages.
ATM (显示 ATM 蛋白) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.
APPL1 enhances glucose uptake by modulating the activation and localization of PKCzeta (显示 PRKCZ 蛋白), as well as its functional interaction with both PP2A (显示 PPP2R2B 蛋白) and myosin IIa.
APPL1-SirT1-STAT3 pathway mediated adiponectin signaling in primary hepatocytes.
Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (显示 TLR4 蛋白)-induced signaling, transcription, and cytokine secretion.
Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (显示 HGF 蛋白)-induced Akt (显示 AKT1 蛋白) activation, migration, and invasion.
In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (显示 PRKAA1 蛋白) signaling.
APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways.
Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.
APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (显示 INS 蛋白) sensitivity.
Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (显示 INS 蛋白) resistance and improves adipoR1 (显示 ADIPOR1 蛋白)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
, DCC-interacting protein 13-alpha
, adapter protein containing PH domain, PTB domain and leucine zipper motif 1
, adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
, signaling adaptor protein DIP13alpha
, DIP13 alpha
, adaptor protein APPL like