ATP Citrate Lyase (ACLY) ELISA试剂盒

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.

list all ELISA KIts 基因 基因ID UniProt
 ACLY ACLY 47 P53396
小鼠 ACLY ACLY 104112 Q91V92
大鼠 ACLY ACLY 24159 P16638
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适于 ACLY 相互作用对的更多 ELISA 试剂盒

Human ATP Citrate Lyase (ACLY) interaction partners

  1. Results show that ACLY was up-regulated in human gastric cancer (GC) tissues and cell lines and a critical downstream target of the tumor suppressor activity of miR (显示 MLXIP ELISA试剂盒)-133b in GC.

  2. ACLY and ACSS2 are both activated to produce cytosolic Ac-CoA from glucose carbon for lipogenesis during human cytomegalovirus infection.

  3. ACLY facilitates histone acetylation at double-strand break (DSB) sites, impairing 53BP1 localization and enabling BRCA1 recruitment and DNA repair by homologous recombination. ACLY phosphorylation and nuclear localization are necessary for its role in promoting BRCA1 recruitment.

  4. The protein crystallized consisted of residues 2-425-ENLYFQ and S-488-810 of human ATP-citrate lyase. (2S,3S)-2-Hydroxycitrate binds in the same orientation as citrate, but the citrate-binding domain (residues 248-421) adopts a different orientation with respect to the rest of the protein (residues 4-247, 490-746 and 748-809) from that previously seen.

  5. CUL3 interacts with ACLY through its adaptor protein, KLHL25 (Kelch-like family member 25), to ubiquitinate and degrade ACLY in cells

  6. we found that depletion of ATP citrate lyase suppressed tumor growth, which suggests that ATP citrate lyase-related inhibitors might be potential therapeutic approaches for breast cancer.

  7. Results show that ACLY is a key phosphoprotein effector of IL-2 (显示 IL2 ELISA试剂盒)-mediated T-cell responses. ACLY becomes phosphorylated on serine 455 in T lymphocytes upon IL-2 (显示 IL2 ELISA试剂盒)-driven activation of AKT (显示 AKT1 ELISA试剂盒), and depletion or inactivation of ACLY compromises IL-2 (显示 IL2 ELISA试剂盒)-promoted T-cell growth.

  8. ACLY was also required for LMW-E-mediated transformation, migration, and invasion of breast cancer cells in vitro along with tumor growth in vivo In clinical specimens of breast cancer, the absence of LMW-E and low expression of adipophilin (PLIN2 (显示 PLIN2 ELISA试剂盒)), a marker of lipid droplet formation, associated with favorable prognosis

  9. ACC1 (显示 ACACA ELISA试剂盒) and ACLY regulate the levels of ETV4 (显示 ETV4 ELISA试剂盒) under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1 (显示 ACACA ELISA试剂盒)/ACLY-alpha-ketoglutarate-ETV4 (显示 ETV4 ELISA试剂盒) axis is a novel means by which metabolic states regulate transcriptional output

  10. ACL activity is associated with increased ATP. Activation of this IGF1 (显示 IGF1 ELISA试剂盒)/ACL/cardiolipin pathway combines anabolic signaling with induction of mechanisms needed to provide required ATP.

Mouse (Murine) ATP Citrate Lyase (ACLY) interaction partners

  1. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase (显示 alphaKGDHC ELISA试剂盒) and induces histone modifications in an ACL (显示 APOC4 ELISA试剂盒)-dependent manner

  2. these data indicate that engagement of acetate metabolism is a crucial, although partial, mechanism of compensation for ACLY deficiency.

  3. ACL (显示 APOC4 ELISA试剂盒) plays a critical role in epigenetic regulation of diabetic renal fibrosis.

  4. ATP-citrate lyase inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr (显示 LDLR ELISA试剂盒) knockout mouse model of metabolic dysregulation.

  5. IL-4 (显示 IL4 ELISA试剂盒) signaling co-opts the Akt (显示 AKT1 ELISA试剂盒)-mTORC1 pathway to regulate Acly, a key enzyme in acetyl-CoA (显示 LPCAT1 ELISA试剂盒) synthesis, leading to increased histone acetylation and macrophage gene induction.

  6. These data demonstrate that ACLY mediates glucose-dependent de novo lipogenesis in response to LPS (显示 TLR4 ELISA试剂盒) signaling and identify a role for ACLY in several phenotypic changes that define plasma cell differentiation

  7. Results suggest a role for DNA methyltransferase 1 (DNMT1 (显示 DNMT1 ELISA试剂盒)) in modulating the timing of differentiation and describe a novel ATP-citrate lyase (ACL)-miR (显示 MLXIP ELISA试剂盒)-148a-dependent mechanism for regulating DNMT1 (显示 DNMT1 ELISA试剂盒) during adipogenesis.

  8. Differences between human and rodent pancreatic islets: low pyruvate carboxylase (显示 PC ELISA试剂盒), atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

  9. Results demonstrate that hepatic ATP-citrate lyase suppression exerts profound effects on triglyceride mobilization as well as fatty acid compositions in the liver, suggesting an important role for ACL (显示 APOC4 ELISA试剂盒) in lipid metabolism.

  10. Data suggest that ATP-citrate lyase (ACLY) expression and activity can be suppressed by exogenous lipids and demonstrate a critical role for ACLY in pancreatic beta cell survival.

Pig (Porcine) ATP Citrate Lyase (ACLY) interaction partners

  1. The results of this study indicate that a C/T mutation affects ACL mRNA expression, probably via the activator protein 2 (显示 TFAP2A ELISA试剂盒).

Cow (Bovine) ATP Citrate Lyase (ACLY) interaction partners

  1. we identified three non-synonymous mutations in ACLY exons in five beef cattle populations. Single nucleotide polymorphism (SNP) g.17127C>T is significantly associated with chest girth and body height, and with body slanting length. SNP g.40427T>C is significantly associated with an increase in chest girth. ACLY gene are associated with growth traits in beef cattle in northwest China

ACLY 抗原简介

Antigen Summary

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with ATP Citrate Lyase (ACLY) ELISA试剂盒

  • ATP citrate lyase (ACLY) 抗体
  • ATP citrate lyase S homeolog (acly.S) 抗体
  • ATP-citrate synthase (LOC587157) 抗体
  • ATP citrate lyase (acly) 抗体
  • ATP citrate lyase (ATPCL) 抗体
  • ATP-citrate synthase (LOC5564509) 抗体
  • citrate synthase, mitochondrial (CpipJ_CPIJ010291) 抗体
  • ATP-citrate synthase (Bm1_26245) 抗体
  • atp-citrate synthase (ACL) 抗体
  • ATP citrate lyase (Acly) 抗体
  • ATP citrate lyase a (aclya) 抗体
  • A730098H14Rik 抗体
  • ACL 抗体
  • acly 抗体
  • anon-WO0140519.179 抗体
  • ATPCL 抗体
  • AW538652 抗体
  • BcDNA:LD21334 抗体
  • cb722 抗体
  • CG8322 抗体
  • Clatp 抗体
  • dATPCL 抗体
  • DDBDRAFT_0205389 抗体
  • DDBDRAFT_0235360 抗体
  • DDB_0205389 抗体
  • DDB_0235360 抗体
  • DmATPCL 抗体
  • Dmel\\CG8322 抗体
  • l(2)01466 抗体
  • l(2)k09217 抗体
  • n(2)k09217 抗体
  • zgc:92008 抗体

Protein level used designations for ATP Citrate Lyase (ACLY) ELISA试剂盒

ATP citrate lyase , ATP citrate synthase , ATP-citrate synthase-like , ATP-citrate lyase , ATPCL-PD , ATPCL-PE , ATPCL-PF , CG8322-PD , CG8322-PE , CG8322-PF , ATP-citrate synthase , citrate synthase, mitochondrial , atp-citrate synthase , ATP-citrate (pro-S-)-lyase , citrate cleavage enzyme

GENE ID SPECIES
100053195 Equus caballus
454672 Pan troglodytes
495086 Xenopus laevis
587157 Strongylocentrotus purpuratus
708501 Macaca mulatta
8621508 Dictyostelium discoideum AX4
100405725 Callithrix jacchus
100422779 Felis catus
100439535 Pongo abelii
100467494 Ailuropoda melanoleuca
36760 Drosophila melanogaster
5564509 Aedes aegypti
6042632 Culex quinquefasciatus
6100149 Brugia malayi
7201075 Phaeodactylum tricornutum CCAP 1055/1
47 Homo sapiens
104112 Mus musculus
24159 Rattus norvegicus
100125957 Sus scrofa
511135 Bos taurus
395373 Gallus gallus
607852 Canis lupus familiaris
654404 Ovis aries
436922 Danio rerio
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