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ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.
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Results show that ACLY was up-regulated in human gastric cancer (GC) tissues and cell lines and a critical downstream target of the tumor suppressor activity of miR (显示 MLXIP ELISA试剂盒)-133b in GC.
ACLY and ACSS2 are both activated to produce cytosolic Ac-CoA from glucose carbon for lipogenesis during human cytomegalovirus infection.
ACLY facilitates histone acetylation at double-strand break (DSB) sites, impairing 53BP1 localization and enabling BRCA1 recruitment and DNA repair by homologous recombination. ACLY phosphorylation and nuclear localization are necessary for its role in promoting BRCA1 recruitment.
The protein crystallized consisted of residues 2-425-ENLYFQ and S-488-810 of human ATP-citrate lyase. (2S,3S)-2-Hydroxycitrate binds in the same orientation as citrate, but the citrate-binding domain (residues 248-421) adopts a different orientation with respect to the rest of the protein (residues 4-247, 490-746 and 748-809) from that previously seen.
CUL3 interacts with ACLY through its adaptor protein, KLHL25 (Kelch-like family member 25), to ubiquitinate and degrade ACLY in cells
we found that depletion of ATP citrate lyase suppressed tumor growth, which suggests that ATP citrate lyase-related inhibitors might be potential therapeutic approaches for breast cancer.
Results show that ACLY is a key phosphoprotein effector of IL-2 (显示 IL2 ELISA试剂盒)-mediated T-cell responses. ACLY becomes phosphorylated on serine 455 in T lymphocytes upon IL-2 (显示 IL2 ELISA试剂盒)-driven activation of AKT (显示 AKT1 ELISA试剂盒), and depletion or inactivation of ACLY compromises IL-2 (显示 IL2 ELISA试剂盒)-promoted T-cell growth.
ACLY was also required for LMW-E-mediated transformation, migration, and invasion of breast cancer cells in vitro along with tumor growth in vivo In clinical specimens of breast cancer, the absence of LMW-E and low expression of adipophilin (PLIN2 (显示 PLIN2 ELISA试剂盒)), a marker of lipid droplet formation, associated with favorable prognosis
ACC1 (显示 ACACA ELISA试剂盒) and ACLY regulate the levels of ETV4 (显示 ETV4 ELISA试剂盒) under hypoxia via increased alpha-ketoglutarate. These results reveal that the ACC1 (显示 ACACA ELISA试剂盒)/ACLY-alpha-ketoglutarate-ETV4 (显示 ETV4 ELISA试剂盒) axis is a novel means by which metabolic states regulate transcriptional output
ACL activity is associated with increased ATP. Activation of this IGF1 (显示 IGF1 ELISA试剂盒)/ACL/cardiolipin pathway combines anabolic signaling with induction of mechanisms needed to provide required ATP.
We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase (显示 alphaKGDHC ELISA试剂盒) and induces histone modifications in an ACL (显示 APOC4 ELISA试剂盒)-dependent manner
these data indicate that engagement of acetate metabolism is a crucial, although partial, mechanism of compensation for ACLY deficiency.
ACL (显示 APOC4 ELISA试剂盒) plays a critical role in epigenetic regulation of diabetic renal fibrosis.
ATP-citrate lyase inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr (显示 LDLR ELISA试剂盒) knockout mouse model of metabolic dysregulation.
IL-4 (显示 IL4 ELISA试剂盒) signaling co-opts the Akt (显示 AKT1 ELISA试剂盒)-mTORC1 pathway to regulate Acly, a key enzyme in acetyl-CoA (显示 LPCAT1 ELISA试剂盒) synthesis, leading to increased histone acetylation and macrophage gene induction.
These data demonstrate that ACLY mediates glucose-dependent de novo lipogenesis in response to LPS (显示 TLR4 ELISA试剂盒) signaling and identify a role for ACLY in several phenotypic changes that define plasma cell differentiation
Results suggest a role for DNA methyltransferase 1 (DNMT1 (显示 DNMT1 ELISA试剂盒)) in modulating the timing of differentiation and describe a novel ATP-citrate lyase (ACL)-miR (显示 MLXIP ELISA试剂盒)-148a-dependent mechanism for regulating DNMT1 (显示 DNMT1 ELISA试剂盒) during adipogenesis.
Differences between human and rodent pancreatic islets: low pyruvate carboxylase (显示 PC ELISA试剂盒), atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.
Results demonstrate that hepatic ATP-citrate lyase suppression exerts profound effects on triglyceride mobilization as well as fatty acid compositions in the liver, suggesting an important role for ACL (显示 APOC4 ELISA试剂盒) in lipid metabolism.
Data suggest that ATP-citrate lyase (ACLY) expression and activity can be suppressed by exogenous lipids and demonstrate a critical role for ACLY in pancreatic beta cell survival.
The results of this study indicate that a C/T mutation affects ACL mRNA expression, probably via the activator protein 2 (显示 TFAP2A ELISA试剂盒).
we identified three non-synonymous mutations in ACLY exons in five beef cattle populations. Single nucleotide polymorphism (SNP) g.17127C>T is significantly associated with chest girth and body height, and with body slanting length. SNP g.40427T>C is significantly associated with an increase in chest girth. ACLY gene are associated with growth traits in beef cattle in northwest China
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.
ATP citrate lyase
, ATP citrate synthase
, ATP-citrate synthase-like
, ATP-citrate lyase
, ATP-citrate synthase
, citrate synthase, mitochondrial
, atp-citrate synthase
, ATP-citrate (pro-S-)-lyase
, citrate cleavage enzyme