anti-DISC1 (DISC1) 抗体产品概述

Full name:
anti-Disrupted in Schizophrenia 1 抗体 (DISC1)
在www.antibodies-online.cn可供189 Disrupted in Schizophrenia 1 (DISC1) 抗体的24不同的供货商。 再加上,我们可以发DISC1 蛋白 (9)DISC1 试剂盒 (3)和数多这个蛋白质的别的产品。 总共213 DISC1产品已列进来了。
别名:
C1orf136, DISC1, SCZD9

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引用最多的anti-DISC1 抗体

  1. Human Polyclonal DISC1 Primary Antibody for EIA, WB - ABIN492932 : Camargo, Wang, Brandon: What can we learn from the disrupted in schizophrenia 1 interactome: lessons for target identification and disease biology? in Novartis Foundation symposium 2008 (PubMed)
    Show all 3 references for 492932

  2. Human Polyclonal DISC1 Primary Antibody for EIA, FACS - ABIN951917 : Park, Jeong, Lee, Mun, Kim, Lee, Nguyen, Han, Suh, Park: Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 3 references for 951917

  3. Human Polyclonal DISC1 Primary Antibody for FACS, IHC (p) - ABIN658716 : Raznahan, Lee, Long, Greenstein, Clasen, Addington, Rapoport, Giedd: Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents. in Molecular psychiatry 2011 (PubMed)
    Show all 3 references for 658716

  4. Human Polyclonal DISC1 Primary Antibody for IHC (fro), WB - ABIN2473343 : Taya, Shinoda, Tsuboi, Asaki, Nagai, Hikita, Kuroda, Kuroda, Shimizu, Hirotsune, Iwamatsu, Kaibuchi: DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)

  5. Mouse (Murine) Polyclonal DISC1 Primary Antibody for ICC, IHC (fro) - ABIN258331 : El-Hassar, Simen, Duque, Patel, Kaczmarek, Arnsten, Yeckel: Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels. in Biological psychiatry 2014 (PubMed)

  6. Human Polyclonal DISC1 Primary Antibody for ELISA, WB - ABIN190904 : Millar, Pickard, Mackie, James, Christie, Buchanan, Malloy, Chubb, Huston, Baillie, Thomson, Hill, Brandon, Rain, Camargo, Whiting, Houslay, Blackwood, Muir, Porteous: DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. in Science (New York, N.Y.) 2005 (PubMed)

更多抗DISC1的相互作用对抗体

Zebrafish Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. A Disc1 peptide binds to GSK3beta (显示 GSK3b 抗体), and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin (显示 CTNNB1 抗体)-mediated Wnt (显示 WNT2 抗体) signaling and inhibiting GSK3beta (显示 GSK3b 抗体) activity.

  2. Disc1 and nrg1 (显示 NRG1 抗体) function in controlling development of oligodendrocytes and neurones from olig2 (显示 OLIG2 抗体)-expressing precursor cells.

  3. Disc1 functions in the transcriptional repression of foxd3 (显示 FOXD3 抗体) and sox10 (显示 SOX10 抗体), thus mediating cranial neural crest cell migration and differentiation.

Human Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. HTT (显示 HTT 抗体) forms a ternary protein complex with the scaffolding protein DISC1 and cAMP-degrading phosphodiesterase 4 (PDE4 (显示 PDE4A 抗体)) to regulate PDE4 (显示 PDE4A 抗体) activity.

  2. This theme highlights the importance of understanding precisely how DISC1 can regulate intracellular trafficking, and suggests that a novel approach to the treatment of psychiatric disorders could be provided by targeting this protein and the trafficking machinery with which it interacts.

  3. Findings indicate that disrupted-in-schizophrenia 1 (DISC1) and close homolog of L1 (显示 CHL1 抗体) may engage in physical and functional interaction in neural development, supporting the notion that DISC1 regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.

  4. DISC1 increased the risk for late-onset Alzheimer's disease in northern Han Chinese population.

  5. Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta (显示 GSK3b 抗体) phosphorylation.

  6. DISC1 has distinctly folded regions, which are bisected by mental illness-related mutations

  7. These results should contribute to reveal DISC1 physiological function and potential pathogenic role in severe mental illnesses

  8. This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 (显示 NRG1 抗体) genes could be associated with schizophrenia in the Chinese population.

  9. This study demonstrated that the Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia.

  10. The present findings, at least in part, provide some clues for further investigating the association of DISC1 variants with SCZ susceptibility

Mouse (Murine) Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. Co-disruption of DISC1 and NRG1 (显示 NRG1 抗体), indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin (显示 AVP 抗体) gene expression in a mouse schizophrenia model.

  2. the 100P mutation in Disc1 prevents expression of parvalbumin (显示 PVALB 抗体) by a normally sized cohort of interneurons and altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin (显示 PVALB 抗体) expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons.

  3. mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons

  4. abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.

  5. Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta (显示 GSK3b 抗体) signaling and sex-dependent behavioral effects in mice

  6. Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.

  7. Hypoxic preconditioning decreases NF-kappaB (显示 NFKB1 抗体) activity via Disc1.

  8. Results indicate that DISC1 attenuates Abeta (显示 APP 抗体) generation and cognitive deficits of APP (显示 APP 抗体)/PS1 (显示 PSEN1 抗体) transgenic mice through promoting lysosomal degradation of BACE1 (显示 BACE 抗体)

  9. These results suggest that alteration of CB1R (显示 CNR1 抗体)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.

  10. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

DISC1 抗原简介

Antigen Summary

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with DISC1

  • disrupted in schizophrenia 1 (disc1) 抗体
  • disrupted in schizophrenia 1 (DISC1) 抗体
  • disrupted in schizophrenia 1 (Disc1) 抗体
  • C1orf136 抗体
  • DISC1 抗体
  • SCZD9 抗体

Protein level used designations for DISC1

disrupted in schizophrenia 1 protein , disrupted in schizophrenia 1 , disrupted in schizophrenia 1 homolog

GENE ID SPECIES
407621 Danio rerio
719086 Macaca mulatta
742093 Pan troglodytes
100060246 Equus caballus
488970 Canis lupus familiaris
613555 Bos taurus
100156849 Sus scrofa
100356059 Oryctolagus cuniculus
100580606 Nomascus leucogenys
27185 Homo sapiens
244667 Mus musculus
307940 Rattus norvegicus
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