DISC1 产品
(Disrupted in Schizophrenia 1 (DISC1))
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This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
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Featured DISC1 Categories
DISC1 抗体
High quality antibodies with extensive validation data.
DISC1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
DISC1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DISC1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7439720
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN7260711
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
Cat. No.
ABIN7150092
Quantity
100 μg
Datasheet
Datasheet
Recommended DISC1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1129956
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1129954
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1129955
Quantity
96 tests
Datasheet
Datasheet
Recommended DISC1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3092106
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3136109
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7405693
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our DISC1 Products
: "Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels." in: Biological psychiatry, Vol. 76, Issue 6, pp. 476-85, (2014) (PubMed).: "Disrupted-in-Schizophrenia 1 (DISC1) is necessary for the correct migration of cortical interneurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 2, pp. 738-45, (2012) (PubMed).
: "Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding." in: Human molecular genetics, Vol. 17, Issue 16, pp. 2462-73, (2008) (PubMed).
: "DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 1, pp. 15-26, (2007) (PubMed).
: "Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain." in: Cell, Vol. 130, Issue 6, pp. 1146-58, (2007) (PubMed).
: "Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 10, pp. 3828-33, (2005) (PubMed).
: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." in: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, (2005) (PubMed).
: "Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders." in: Molecular and cellular neurosciences, Vol. 25, Issue 1, pp. 42-55, (2004) (PubMed).
: "Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder." in: American journal of human genetics, Vol. 75, Issue 5, pp. 862-72, (2004) (PubMed).
: "Evolutionary constraints on the Disrupted in Schizophrenia locus." in: Genomics, Vol. 81, Issue 1, pp. 67-77, (2003) (PubMed).
Synonyms and alternative names related to DISC1
disrupted in schizophrenia 1 (disc1), disrupted in schizophrenia 1 (DISC1), disrupted in schizophrenia 1 protein (LOC100580606), disrupted in schizophrenia 1 (Disc1), C1orf136, DISC1, SCZD9Protein level used designations for DISC1
- disrupted in schizophrenia 1 protein
- disrupted in schizophrenia 1
- disrupted in schizophrenia 1 homolog
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